Purified Malaria Pigment (Hemozoin) Enhances Dendritic Cell Maturation and Modulates the Isotype of Antibodies Induced by a DNA Vaccine

DOI Web Site 被引用文献5件
  • Cevayir Coban
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore
  • Ken J. Ishii
    Division of Viral Products, Center for Biological Evaluation and Research/Food and Drug Administration, Bethesda, Maryland
  • David J. Sullivan
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore
  • Nirbhay Kumar
    Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore

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<jats:title>ABSTRACT</jats:title><jats:p>Hemozoin (malaria pigment) has been implicated in the modulation of immune responses during malaria infection. This study was designed to evaluate the effect of purified hemozoin on the in vitro activation of myeloid dendritic cells. Our study also revealed that in addition to enhancing the maturation of dendritic cells, hemozoin also greatly promotes immunoglobulin G2a antibody responses when coadministered with a DNA vaccine plasmid encoding Pfs25, a<jats:italic>Plasmodium falciparum</jats:italic>transmission-blocking antigen.</jats:p>

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