Role of the High-Affinity Zinc Uptake <i>znuABC</i> System in <i>Salmonella enterica</i> Serovar Typhimurium Virulence

DOI Web Site 2 Citations
  • Susana Campoy
    Department of Genetics and Microbiology, Universitat Autònoma de Barcelona
  • Mónica Jara
    Department of Genetics and Microbiology, Universitat Autònoma de Barcelona
  • Núria Busquets
    Department of Genetics and Microbiology, Universitat Autònoma de Barcelona
  • Ana M. Pérez de Rozas
    Centre de Recerca en Sanitat Animal (CReSA), Universitat Autònoma de Barcelona Institut de Recerca i Tecnologia Agroalimentària (UAB-IRTA), Bellaterra 08193, Barcelona, Spain
  • Ignacio Badiola
    Centre de Recerca en Sanitat Animal (CReSA), Universitat Autònoma de Barcelona Institut de Recerca i Tecnologia Agroalimentària (UAB-IRTA), Bellaterra 08193, Barcelona, Spain
  • Jordi Barbé
    Department of Genetics and Microbiology, Universitat Autònoma de Barcelona

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Abstract

<jats:title>ABSTRACT</jats:title> <jats:p> The <jats:italic>Salmonella enterica</jats:italic> serovar Typhimurium <jats:italic>znuABC</jats:italic> genes encoding a high-affinity zinc uptake system and its regulatory <jats:italic>zur</jats:italic> gene have been cloned. <jats:italic>Salmonella</jats:italic> serovar Typhimurium <jats:italic>zur</jats:italic> and <jats:italic>znuC</jats:italic> knockout mutants have been constructed by marker exchange. The 50% lethal dose of the <jats:italic>znuC</jats:italic> mutant increased when either orally or intraperitoneally inoculated in BALB/c mice, while virulence of the <jats:italic>zur</jats:italic> mutant decreased only when mice were intraperitoneally challenged. </jats:p>

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