Antibiotic Resistance of <i>Helicobacter pylori</i> Strains in Japanese Children
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- Seiichi Kato
- Department of Pediatrics, Tohoku University School of Medicine, Sendai
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- Shigeru Fujimura
- Department of Microbiology, Miyagi University, Miyagi
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- Hirokazu Udagawa
- Otsuka Tokyo Assay Laboratories
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- Toshiaki Shimizu
- Department of Pediatrics, Juntedo University School of Medicine, Tokyo
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- Shunichi Maisawa
- Morioka Children's Hospital, Morioka, Japan
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- Kyoko Ozawa
- Department of Pediatrics, Tohoku University School of Medicine, Sendai
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- Kazuie Iinuma
- Department of Pediatrics, Tohoku University School of Medicine, Sendai
抄録
<jats:title>ABSTRACT</jats:title> <jats:p> The resistance of <jats:italic>Helicobacter pylori</jats:italic> to the recently available antibiotic treatment regimens has been a growing problem. We investigated the prevalence of <jats:italic>H. pylori</jats:italic> resistance to clarithromycin, metronidazole, and amoxicillin among 51 <jats:italic>H. pylori</jats:italic> isolates from Japanese children. In addition, the mutations of the corresponding gene were studied by PCR and restriction fragment length polymorphism analysis. Primary resistance to clarithromycin, metronidazole, and amoxicillin was detected in 29, 24, and 0% of strains, respectively. The eradication rates in clarithromycin-susceptible and -resistant strains were 89 and 56%, respectively ( <jats:italic>P</jats:italic> < 0.05). The prevalence of strains with acquired resistance to clarithromycin (78%) was higher than that of strains with primary resistance ( <jats:italic>P</jats:italic> < 0.01). Among the clarithromycin-resistant strains studied, 92% showed cross-resistance to azithromycin. No acquired resistance to amoxicillin was demonstrated. The A2144G mutation in the 23S rRNA gene was detected in 11 of 12 (92%) clarithromycin-resistant strains tested, whereas the mutation was not detected in any of the 15 susceptible strains. The deletion of the <jats:italic>rdxA</jats:italic> gene was not demonstrated in any of the strains. The results indicate that a high prevalence of clarithromycin-resistant strains is associated with eradication failure. Testing of susceptibility to clarithromycin is recommended. </jats:p>
収録刊行物
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- Journal of Clinical Microbiology
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Journal of Clinical Microbiology 40 (2), 649-653, 2002-02
American Society for Microbiology
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詳細情報 詳細情報について
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- CRID
- 1360292621106095360
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- NII論文ID
- 30021101825
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- ISSN
- 1098660X
- 00951137
- http://id.crossref.org/issn/00951137
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