Epidemiology of <i>Aspergillus terreus</i> at a University Hospital

DOI Web Site 被引用文献4件
  • John W. Baddley
    Department of Medicine, Division of Infectious Diseases
  • Peter G. Pappas
    Department of Medicine, Division of Infectious Diseases
  • Anita C. Smith
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama
  • Stephen A. Moser
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama

抄録

<jats:title>ABSTRACT</jats:title> <jats:p> Invasive fungal infections due to <jats:italic>Aspergillus</jats:italic> species have become a major cause of morbidity and mortality among immunocompromised patients. <jats:italic>Aspergillus terreus</jats:italic> , a less common pathogen, appears to be an emerging cause of infection at our institution, the University of Alabama hospital in Birmingham. We therefore investigated the epidemiology of <jats:italic>A. terreus</jats:italic> over the past 6 years by using culture data; antifungal susceptibility testing with amphotericin B, voriconazole, and itraconazole; and molecular typing with random amplification of polymorphic DNA-PCR (RAPD-PCR). During the study period, the percentage of <jats:italic>A. terreus</jats:italic> isolates relative to those of other <jats:italic>Aspergillus</jats:italic> species significantly increased, and <jats:italic>A. terreus</jats:italic> isolates frequently were resistant to amphotericin B. Molecular typing with the RAPD technique was useful in discriminating between patient isolates, which showed much strain diversity. Further surveillance of <jats:italic>A. terreus</jats:italic> may better define epidemiology and determine whether this organism is becoming more frequent in relation to other <jats:italic>Aspergillus</jats:italic> species. </jats:p>

収録刊行物

被引用文献 (4)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ