Vitamin D Receptor Gene <i>Fok</i>1 Polymorphism Predicts Calcium Absorption and Bone Mineral Density in Children

DOI PDF Web Site 被引用文献9件
  • Sharla K. Ames
    Children's Nutrition Research Center, U.S. Department of Agriculture/Agricultural Research Service, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, U.S.A.
  • Kenneth J. Ellis
    Children's Nutrition Research Center, U.S. Department of Agriculture/Agricultural Research Service, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, U.S.A.
  • Sheila K. Gunn
    Division of Endocrinology and Metabolism, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, U.S.A.
  • Kenneth C. Copeland
    Division of Endocrinology and Metabolism, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, U.S.A.
  • Steven A. Abrams
    Children's Nutrition Research Center, U.S. Department of Agriculture/Agricultural Research Service, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, U.S.A.

抄録

<jats:title>Abstract</jats:title> <jats:p>The vitamin D receptor (VDR) gene has been implicated as one of the major genetic components of osteoporosis. We evaluated the relationship between markers of mineral status and restriction fragment length polymorphisms of the VDR gene in 72 healthy children age 7–12 years. Using stable isotope techniques and dual-energy X-ray absorptiometry, we measured dietary calcium absorption, bone calcium deposition rates, and total body bone mineral density (BMD). The Fok1 polymorphism at the VDR translation initiation site was significantly associated with BMD (p = 0.02) and calcium absorption (p = 0.04). Children who were FF homozygotes had a mean calcium absorption that was 41.5% greater than those who were ff homozygotes and 17% greater absorption than Ff heterozygotes. BMD was 8.2% greater in the FF genotype than the ff genotype and 4.8% higher than the Ff genotype. These results suggest a substantial relationship between the VDR gene and bone metabolism at one or more levels, including dietary absorption of calcium and BMD in growing children.</jats:p>

収録刊行物

被引用文献 (9)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ