-
- Chih-Jen Wei
- Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892;
-
- Xin Xu
- Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892;
-
- Cecilia W. Lo
- Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892;
抄録
<jats:p> ▪ Abstract Gap junctions contain hydrophilic membrane channels that allow direct communication between neighboring cells through the diffusion of ions, metabolites, and small cell signaling molecules. They are made up of a hexameric array of polypeptides encoded by the connexin multi-gene family. Cell-cell communication mediated by connexins is crucial to various cellular functions, including the regulation of cell growth, differentiation, and development. Mutations in connexin genes have been linked to a variety of human diseases, including cardiovascular anomalies, peripheral neuropathy, deafness, skin disorders, and cataracts. In addition to their coupling function, recent studies suggest that connexin proteins may also mediate signaling. This could involve interactions with other protein partners that may play a role not only in connexin assembly, trafficking, gating and turnover, but also in the coordinate regulation of cell-cell communication with cell adhesion and cell motility. The integration of these cell functions is likely to be important in the role of gap junctions in development and disease. </jats:p>
収録刊行物
-
- Annual Review of Cell and Developmental Biology
-
Annual Review of Cell and Developmental Biology 20 (1), 811-838, 2004-11-01
Annual Reviews
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1363670318359602304
-
- NII論文ID
- 30022117823
-
- ISSN
- 15308995
- 10810706
-
- データソース種別
-
- Crossref
- CiNii Articles