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- Timothy K. Starr
- Center for Immunology and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455;, ,
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- Stephen C. Jameson
- Center for Immunology and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455;, ,
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- Kristin A. Hogquist
- Center for Immunology and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455;, ,
抄録
<jats:p>A functional immune system requires the selection of T lymphocytes expressing receptors that are major histocompatibility complex restricted but tolerant to self-antigens. This selection occurs predominantly in the thymus, where lymphocyte precursors first assemble a surface receptor. In this review we summarize the current state of the field regarding the natural ligands and molecular factors required for positive and negative selection and discuss a model for how these disparate outcomes can be signaled via the same receptor. We also discuss emerging data on the selection of regulatory T cells. Such cells require a high-affinity interaction with self-antigens, yet differentiate into regulatory cells instead of being eliminated.</jats:p>
収録刊行物
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- Annual Review of Immunology
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Annual Review of Immunology 21 (1), 139-176, 2003-04
Annual Reviews
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詳細情報
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- CRID
- 1360292620974175232
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- NII論文ID
- 30022122380
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- ISSN
- 15453278
- 07320582
- http://id.crossref.org/issn/07320582
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- データソース種別
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- Crossref
- CiNii Articles