D<scp>IVERSITY AND</scp> R<scp>EGULATION OF</scp> P<scp>LANT</scp> Ca²⁺ P<scp>UMPS</scp>: Insights from Expression in Yeast

• Heven Sze

  Department of Cell Biology and Molecular Genetics, and Maryland Agricultural Experiment Station, University of Maryland, College Park, Maryland 20742;

• Feng Liang

  Department of Cell Biology and Molecular Genetics, and Maryland Agricultural Experiment Station, University of Maryland, College Park, Maryland 20742;

• Ildoo Hwang

  Department of Cell Biology and Molecular Genetics, and Maryland Agricultural Experiment Station, University of Maryland, College Park, Maryland 20742;

• Amy C. Curran

  Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037

• Jeffrey F. Harper

  Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037

抄録

▪ Abstract  The spatial and temporal regulation of calcium concentration in plant cells depends on the coordinate activities of channels and active transporters located on different organelles and membranes. Several Ca 2+ pumps have been identified and characterized by functional expression of plant genes in a yeast mutant (K616). This expression system has opened the way to a genetic and biochemical characterization of the regulatory and catalytic features of diverse Ca 2+ pumps. Plant Ca 2+ -ATPases fall into two major types: AtECA1 represents one of four or more members of the type IIA (ER-type) Ca 2+ -ATPases in Arabidopsis, and AtACA2 is one of seven or more members of the type IIB (PM-type) Ca 2+ -ATPases that are regulated by a novel amino terminal domain. Type IIB pumps are widely distributed on membranes, including the PM (plasma membrane), vacuole, and ER (endoplasmic reticulum). The regulatory domain serves multiple functions, including autoinhibition, calmodulin binding, and sites for modification by phosphorylation. This domain, however, is considerably diverse among several type IIB ATPases, suggesting that the pumps are differentially regulated. Understanding of Ca 2+ transporters at the molecular level is providing insights into their roles in signaling networks and in regulating fundamental processes of cell biology.

収録刊行物

• Annual Review of Plant Physiology and Plant Molecular Biology

  Annual Review of Plant Physiology and Plant Molecular Biology 51 (1), 433-462, 2000-06

  Annual Reviews

キーワード

• General Medicine

詳細情報

• CRID: 1360574094583331072
• NII論文ID: 30022123254
• NII書誌ID: AA10675563
• DOI: 10.1146/annurev.arplant.51.1.433
• ISSN: 10402519
• Web Site: https://www.annualreviews.org/doi/pdf/10.1146/annurev.arplant.51.1.433
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