Spectrum of Hantavirus Infection: Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome

• C. J. Peters, MD

  Centers for Disease Control and Prevention, Atlanta, Georgia 30333;

• Gary L. Simpson, MD, PhD, MPH

  New Mexico Department of Health, Santa Fe, New Mexico 87502

• H. Levy, MD, PhD

  University of New Mexico School of Medicine, Albuquerque, New Mexico 87131-5271

抄録

Hantaviruses chronically infect rodents without apparent disease, but when they are spread by aerosolized excreta to humans, two major clinical syndromes result: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Both diseases appear to be immunopathologic, and inflammatory mediators are important in causing the clinical manifestations. In HPS, T cells act on heavily infected pulmonary endothelium, and it is suspected that gamma interferon and tumor necrosis factor are major agents of a reversible increase in vascular permeability that leads to severe, noncardiogenic pulmonary edema. HFRS has prominent systemic manifestations. The retroperitoneum is a major site of vascular leak and the kidneys suffer tubular necrosis. Both syndromes are accompanied by myocardial depression and hypotension or shock. HFRS is primarily a Eurasian disease, whereas HPS appears to be confined to the Americas; these geographic distinctions correlate with the phylogenies of the rodent hosts and the viruses that coevolved with them.

収録刊行物

• Annual Review of Medicine

  Annual Review of Medicine 50 (1), 531-545, 1999-02

  Annual Reviews

キーワード

• General Biochemistry, Genetics and Molecular Biology
• General Medicine

詳細情報

• CRID: 1363107368925054976
• NII論文ID: 30022132688
• DOI: 10.1146/annurev.med.50.1.531
• ISSN: 1545326X
• ISSN: 00664219
• Web Site: https://www.annualreviews.org/doi/pdf/10.1146/annurev.med.50.1.531
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