THE CHLORIDE CELL:Structure and Function in the Gills of Freshwater Fishes

• Steve F. Perry

  Department of Biology, University of Ottawa, Ottawa, 30 Marie Curie, Ontario K1N 6N5, Canada

抄録

▪ Abstract  This review focuses on the structure and function of the branchial chloride cell in freshwater fishes. The mitochondria-rich chloride cell is believed to be the principal site of trans-epithelial Ca 2+ and Cl − influxes. Though currently debated, there is accruing evidence that the pavement cell is the site of Na + uptake via channels linked electrically to an apical membrane vacuolar H + -ATPase (proton pump). Chloride cells perform an integral role in acid-base regulation. During conditions of alkalosis, the surface area of exposed chloride cells is increased, which serves to enhance base equivalent excretion as the rate of Cl − /HCO 3 − exchange is increased. Conversely, during acidosis, the chloride cell surface area is diminished by an expansion of the adjacent pavement cells. This response reduces the number of functional Cl − /HCO 3 − exchangers. Under certain conditions that challenge ion regulation, chloride cells proliferate on the lamellae. This response, while optimizing the Ca 2+ and Cl − transport capacity of the gill, causes a thickening of the blood-to-water diffusion barrier and thus impedes respiratory gas transfer.

収録刊行物

• Annual Review of Physiology

  Annual Review of Physiology 59 (1), 325-347, 1997-10

  Annual Reviews

キーワード

• Physiology

詳細情報

• CRID: 1360011143944774656
• NII論文ID: 30022153583
• DOI: 10.1146/annurev.physiol.59.1.325
• ISSN: 15451585
• ISSN: 00664278
• Web Site: https://www.annualreviews.org/doi/pdf/10.1146/annurev.physiol.59.1.325
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