Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization

DOI PDF 被引用文献22件
  • Christopher Heeschen
    From the Molecular Cardiology, Department of Internal Medicine IV and Hematology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany.
  • Alexandra Aicher
    From the Molecular Cardiology, Department of Internal Medicine IV and Hematology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany.
  • Ralf Lehmann
    From the Molecular Cardiology, Department of Internal Medicine IV and Hematology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany.
  • Stephan Fichtlscherer
    From the Molecular Cardiology, Department of Internal Medicine IV and Hematology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany.
  • Mariuca Vasa
    From the Molecular Cardiology, Department of Internal Medicine IV and Hematology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany.
  • Carmen Urbich
    From the Molecular Cardiology, Department of Internal Medicine IV and Hematology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany.
  • Christiane Mildner-Rihm
    From the Molecular Cardiology, Department of Internal Medicine IV and Hematology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany.
  • Hans Martin
    From the Molecular Cardiology, Department of Internal Medicine IV and Hematology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany.
  • Andreas M. Zeiher
    From the Molecular Cardiology, Department of Internal Medicine IV and Hematology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany.
  • Stefanie Dimmeler
    From the Molecular Cardiology, Department of Internal Medicine IV and Hematology, Department of Internal Medicine III, University of Frankfurt, Frankfurt, Germany.

抄録

<jats:title>Abstract</jats:title><jats:p>Increasing evidence suggests that postnatal neovascularization involves the recruitment of circulating endothelial progenitor cells (EPCs). Hematopoietic and endothelial cell lineages share common progenitors. Cytokines formerly thought to be specific for the hematopoietic system have only recently been shown to affect several functions in endothelial cells. Accordingly, we investigated the stimulatory potential of erythropoietin (Epo) on EPC mobilization and neovascularization. The bone marrow of Epo-treated mice showed a significant increase in number and proliferation of stem and progenitor cells as well as in colony-forming units. The number of isolated EPCs and CD34+/flk-1+ precursor cells was significantly increased in spleen and peripheral blood of Epo-treated mice compared with phosphate-buffered saline–treated mice. In in vivo models of postnatal neovascularization, Epo significantly increased inflammation- and ischemia-induced neovascularization. The physiologic relevance of these findings was investigated in patients with coronary heart disease. In a multivariate regression model, serum levels of Epo and vascular endothelial growth factor were significantly associated with the number of stem and progenitor cells in the bone marrow as well as with the number and function of circulating EPCs. In conclusion, the present study suggests that Epo stimulates postnatal neovascularization at least in part by enhancing EPC mobilization from the bone marrow. Epo appears to physiologically regulate EPC mobilization in patients with ischemic heart disease. Thus, Epo serum levels may help in identifying patients with impaired EPC recruitment capacity.</jats:p>

収録刊行物

  • Blood

    Blood 102 (4), 1340-1346, 2003-08-15

    American Society of Hematology

被引用文献 (22)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ