The HIF family member EPAS1/HIF-2α is required for normal hematopoiesis in mice

DOI PDF 被引用文献4件
  • Marzia Scortegagna
    From the Departments of Internal Medicine and Pathology, University of Texas Southwestern Medical Center (UTSWMC), Dallas.
  • Margaret A. Morris
    From the Departments of Internal Medicine and Pathology, University of Texas Southwestern Medical Center (UTSWMC), Dallas.
  • Yavuz Oktay
    From the Departments of Internal Medicine and Pathology, University of Texas Southwestern Medical Center (UTSWMC), Dallas.
  • Michael Bennett
    From the Departments of Internal Medicine and Pathology, University of Texas Southwestern Medical Center (UTSWMC), Dallas.
  • Joseph A. Garcia
    From the Departments of Internal Medicine and Pathology, University of Texas Southwestern Medical Center (UTSWMC), Dallas.

抄録

<jats:title>Abstract</jats:title><jats:p>Hypoxic stress plays a role in pathophysiologic states such as myocardial infarction and cerebral vascular events as well as in normal physiologic conditions including development and hematopoiesis. Members of the hypoxia inducible factor (HIF) family function as transcriptional regulators of genes involved in the hypoxic response. After generating adult mice that globally lack endothelial PAS domain protein 1 (EPAS1, also known as HIF-2α/HRF/HLF/MOP3), the second member of the HIF family, characterization of the hematopoietic cell population indicated that the loss of EPAS1/HIF-2α resulted in pancytopenia. Using bone marrow reconstitution experiments of lethally irradiated hosts, we have defined the extent and site of hematopoietic impairment in the EPAS1/HIF-2α null mice. These data suggest a critical role for EPAS1/HIF-2α in maintaining a functional microenvironment in the bone marrow for effective hematopoiesis.</jats:p>

収録刊行物

  • Blood

    Blood 102 (5), 1634-1640, 2003-09-01

    American Society of Hematology

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