Recent insights into the role of Notch signaling in tumorigenesis

DOI PDF 被引用文献17件
  • Kevin G. Leong
    From the Department of Medical Biophysics and the Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver; and the Experimental Medicine Program and the Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
  • Aly Karsan
    From the Department of Medical Biophysics and the Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver; and the Experimental Medicine Program and the Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

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<jats:title>Abstract</jats:title><jats:p>Members of the Notch family of transmembrane receptors play an important role in cell fate determination. Over the past decade, a role for Notch in the pathogenesis of hematologic and solid malignancies has become apparent. Numerous cellular functions and microenvironmental cues associated with tumorigenesis are modulated by Notch signaling, including proliferation, apoptosis, adhesion, epithelial-to-mesenchymal transition, and angiogenesis. It is becoming increasingly evident that Notch signaling can be both oncogenic and tumor suppressive. This review highlights recent findings regarding the molecular and functional aspects of Notch-mediated neoplastic transformation. In addition, cellular mechanisms that potentially explain the complex role of Notch in tumorigenesis are discussed.</jats:p>

収録刊行物

  • Blood

    Blood 107 (6), 2223-2233, 2006-03-15

    American Society of Hematology

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