The biological activity of retinoic acid in the domestic fowl and the effects of vitamin A deficiency on the chick embryo

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<jats:p>1. Male and female chickens were reared from hatching on vitamin A-free diets, either unsupplemented or containing retinoic acid (vitamin A acid), methyl retinoate or retinyl acetate (vitamin A acetate). The birds given retinyl acetate grew well and had a normal appearance, but those given the unsupplemented diet died before 4 weeks of age after developing typical signs of avitaminosis A. The birds given retinoic acid or methyl retinoate did not show overt signs of vitamin A deficiency or other abnormalities except for a progressive failure of vision. Minimal histological changes were found in their retinas, and their vision was rapidly restored after feeding with retinyl acetate.</jats:p><jats:p>2. The cocks maintained with retinoic acid or methyl retinoate had normal testes and the hens laid eggs at a normal rate, but although their eggs could be obtained fertile the development of the embryo became abnormal after 2 days incubation and it always died. The development of the embryos could be stimulated and sometimes restored to normal by injection of various forms of vitamin A into the eggs before incubation, or by previous administration of retinyl acetate to the hens.</jats:p><jats:p>3. It is concluded that feeding retinoic acid as the sole source of vitamin A enables the hen to produce eggs that lack vitamin A but are otherwise normal, thus permitting the demonstration of a hitherto undescribed requirement of the early chick embryo for vitamin A.</jats:p><jats:p>4. The toxicity of vitamin A derivatives to chick embryos was investigated; injected retinoic acid was found to be extremely toxic.</jats:p>

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