Sirolimus-Eluting Stents for the Treatment of Obstructive Superficial Femoral Artery Disease

• Stephan H. Duda

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Benjamin Pusich

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Goetz Richter

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Peter Landwehr

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Vincent L. Oliva

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Alexander Tielbeek

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Benjamin Wiesinger

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Jan Bart Hak

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Hans Tielemans

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Gerhard Ziemer

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Ecatarina Cristea

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Alexandra Lansky

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

• Jean P. Bérégi

  From the Department of Diagnostic Radiology (S.H.D., B.P., B.W.) and the Division of Thoracic, Cardiac, and Vascular Surgery (G.Z.), the University of Tübingen, Tübingen, Germany; the Department of Diagnostic Radiology (G.R.), University of Heidelberg, Heidelberg, Germany; the Department of Radiology, Henriettenstiftung (P.L.), Hannover, Germany; the Department of Diagnostic Radiology (J.P.B.), University of Lille, Lille, France; the Department of Radiology (V.L.O.), University of Montréal,...

書誌事項

タイトル別名

• Six-Month Results

抄録

Background— Stent implantation for obstructive femoropopliteal artery disease has been associated with poor long-term outcomes. This study evaluated the effectiveness of shape memory alloy recoverable technology (SMART) nitinol self-expanding stents coated with a polymer impregnated with sirolimus (rapamycin) versus uncoated SMART stents in superficial femoral artery obstructions. Methods and Results— Thirty-six patients were recruited for this double-blind, randomized, prospective trial. All patients had chronic limb ischemia and femoral artery occlusions (57%) or stenoses (average lesion length, 85±57 mm). Patients were eligible for randomization after successful guidewire passage across the lesion. Eighteen patients received sirolimus-eluting SMART stents and 18 patients received uncoated SMART stents. The primary end point of the study was the in-stent mean percent diameter stenosis, as measured by quantitative angiography at 6 months. The in-stent mean percent diameter stenosis was 22.6% in the sirolimus-eluting stent group versus 30.9% in the uncoated stent group ( P =0.294). The in-stent mean lumen diameter was significantly larger in the sirolimus-eluting stent group (4.95 mm versus 4.31 mm in the uncoated stent group; P =0.047). No serious adverse events (death or prolonged hospitalization) were reported. Conclusions— The use of sirolimus-eluting SMART stents for superficial femoral artery occlusion is feasible, with a trend toward reducing late loss compared with uncoated stents. The coated stent also proved to be safe and was not associated with any serious adverse events.

収録刊行物

• Circulation

  Circulation 106 (12), 1505-1509, 2002-09-17

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Physiology (medical)
• Cardiology and Cardiovascular Medicine

詳細情報

• CRID: 1361981471227583488
• NII論文ID: 30022667583
• DOI: 10.1161/01.cir.0000029746.10018.36
• ISSN: 15244539
• ISSN: 00097322
• Web Site: https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000029746.10018.36
• データソース種別:
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  • CiNii Articles