Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure

DOI Web Site 被引用文献43件
  • Milton Packer
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Michael B. Fowler
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Ellen B. Roecker
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Andrew J.S. Coats
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Hugo A. Katus
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Henry Krum
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Paul Mohacsi
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Jean L. Rouleau
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Michal Tendera
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Christoph Staiger
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Terry L. Holcslaw
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • Ildiko Amann-Zalan
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...
  • David L. DeMets
    From the College of Physicians and Surgeons, Columbia University (M.P.), New York, NY; Royal Brompton Hospital (A.J.S.C.), London, UK; Stanford University Medical Center (M.B.F.), Stanford, Calif; Universitaets Klinikum Luebeck (H.A.K.), Luebeck, Germany; Monash University (H.K.), Prahran Victoria, Australia; University Hospital (P.M.), Bern, Switzerland; University Health Network and Mt Sinai Hospital (J.L.R.), Toronto, Canada; Silesian School of Medicine (M.T.), Katowice, Poland; Roche...

書誌事項

タイトル別名
  • Results of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study

抄録

<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> β-Blocking agents improve functional status and reduce morbidity in mild-to-moderate heart failure, but it is not known whether they produce such benefits in severe heart failure. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods and Results—</jats:italic> </jats:bold> We randomly assigned 2289 patients with symptoms of heart failure at rest or on minimal exertion and with an ejection fraction <25% (but not volume-overloaded) to double-blind treatment with either placebo (n=1133) or carvedilol (n=1156) for an average of 10.4 months. Carvedilol reduced the combined risk of death or hospitalization for a cardiovascular reason by 27% ( <jats:italic>P</jats:italic> =0.00002) and the combined risk of death or hospitalization for heart failure by 31% ( <jats:italic>P</jats:italic> =0.000004). Patients in the carvedilol group also spent 27% fewer days in the hospital for any reason ( <jats:italic>P</jats:italic> =0.0005) and 40% fewer days in the hospital for heart failure ( <jats:italic>P</jats:italic> <0.0001). These differences were as a result of both a decrease in the number of hospitalizations and a shorter duration of each admission. More patients felt improved and fewer patients felt worse in the carvedilol group than in the placebo group after 6 months of maintenance therapy ( <jats:italic>P</jats:italic> =0.0009). Carvedilol-treated patients were also less likely than placebo-treated patients to experience a serious adverse event ( <jats:italic>P</jats:italic> =0.002), especially worsening heart failure, sudden death, cardiogenic shock, or ventricular tachycardia. </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusion—</jats:italic> </jats:bold> In euvolemic patients with symptoms at rest or on minimal exertion, the addition of carvedilol to conventional therapy ameliorates the severity of heart failure and reduces the risk of clinical deterioration, hospitalization, and other serious adverse clinical events. </jats:p>

収録刊行物

  • Circulation

    Circulation 106 (17), 2194-2199, 2002-10-22

    Ovid Technologies (Wolters Kluwer Health)

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