Possible Association of Heart Failure Status With Synthetic Balance Between Aldosterone and Dehydroepiandrosterone in Human Heart

DOI Web Site 被引用文献9件
  • Shota Nakamura
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.
  • Michihiro Yoshimura
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.
  • Masafumi Nakayama
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.
  • Teruhiko Ito
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.
  • Yuji Mizuno
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.
  • Eisaku Harada
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.
  • Tomohiro Sakamoto
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.
  • Yoshihiko Saito
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.
  • Kazuwa Nakao
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.
  • Hirofumi Yasue
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.
  • Hisao Ogawa
    From the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (S.N., M.Y., M.N., T.S., H.O.), Kumamoto, Japan; the Division of Cardiology, Kumamoto Aging Research Institute (T.I., Y.M., E.H., H.Y.), Kumamoto, Japan; the First Department of Internal Medicine, Nara Medical University (Y.S.), Nara, Japan; and the Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (K.N.), Kyoto, Japan.

抄録

<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> Aldosterone is produced not only in the adrenal gland but also in the extra-adrenal tissues, including failing human heart. This study examined the production of dehydroepiandrosterone (DHEA) in human heart and elucidated the possible physiological significance. </jats:p> <jats:p> <jats:bold> <jats:italic>Method and Results—</jats:italic> </jats:bold> Using left ventricular tissues obtained at autopsy, reverse transcription–polymerase chain reaction followed by Southern blot analysis revealed the gene expressions of CYP17. By measuring plasma aldosterone and DHEA levels at the coronary sinuses and aortic roots during cardiac catheterization, we found that DHEA but not aldosterone was secreted from control subjects ( <jats:italic>P</jats:italic> <0.0001 and <jats:italic>P</jats:italic> =0.74, respectively), whereas aldosterone but not DHEA was secreted from patients with heart failure ( <jats:italic>P</jats:italic> =0.0017 and <jats:italic>P</jats:italic> =0.67, respectively). To examine the significance of DHEA, we measured myocyte cell sizes and the gene expression of B-type natriuretic peptide (BNP), using a neonatal rat cardiocyte culture system. We found that DHEA (10 <jats:sup>−8</jats:sup> mol/L) significantly inhibited the increase in myocyte cell sizes and BNP mRNA levels upregulated by endothelin-1 ( <jats:italic>P</jats:italic> =0.031 and <jats:italic>P</jats:italic> <0.0001, respectively). </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> CYP17 gene expression and production of DHEA were demonstrated in human control heart. Also, we found that cardiac production of DHEA was suppressed in failing heart. We postulated that DHEA and/or its metabolites exert a cardioprotective action through antihypertrophic effects. </jats:p>

収録刊行物

  • Circulation

    Circulation 110 (13), 1787-1793, 2004-09-28

    Ovid Technologies (Wolters Kluwer Health)

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