Regulation of Vascular Calcification

DOI Web Site 被引用文献12件
  • Cecilia M. Giachelli
    From the Bioengineering Department, University of Washington, Seattle, Wash.
  • Mei Y. Speer
    From the Bioengineering Department, University of Washington, Seattle, Wash.
  • Xianwu Li
    From the Bioengineering Department, University of Washington, Seattle, Wash.
  • Rupak M. Rajachar
    From the Bioengineering Department, University of Washington, Seattle, Wash.
  • Hsueh Yang
    From the Bioengineering Department, University of Washington, Seattle, Wash.

書誌事項

タイトル別名
  • Roles of Phosphate and Osteopontin

抄録

<jats:p>Vascular calcification is prevalent in aging as well as a number of pathological conditions, and it is now recognized as a strong predictor of cardiovascular events in the general population as well as diabetic and end-stage renal disease patients. Vascular calcification is a highly regulated process involving inductive and inhibitory mechanisms. This article focuses on two molecules, phosphate and osteopontin, that have been implicated in the induction or inhibition of vascular calcification, respectively. Elevated phosphate is of interest because hyperphosphatemia is recognized as a major nonconventional risk factor for cardiovascular disease mortality in end-stage renal disease patients. Studies to date suggest that elevated phosphate stimulates smooth muscle cell phenotypic transition and mineralization via the activity of a sodium-dependent phosphate cotransporter. Osteopontin, however, appears to block vascular calcification most likely by preventing calcium phosphate crystal growth and inducing cellular mineral resorption.</jats:p>

収録刊行物

  • Circulation Research

    Circulation Research 96 (7), 717-722, 2005-04-15

    Ovid Technologies (Wolters Kluwer Health)

被引用文献 (12)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ