Influence of Weight Reduction on Blood Pressure

DOI Web Site 被引用文献25件
  • Judith E. Neter
    From the Division of Human Nutrition, Wageningen University (J.E.N., B.E.S., F.J.K., J.M.G.), Wageningen, and the Julius Center for Health Sciences and Primary Care, Utrecht University (D.E.G.), Utrecht, Netherlands.
  • Bianca E. Stam
    From the Division of Human Nutrition, Wageningen University (J.E.N., B.E.S., F.J.K., J.M.G.), Wageningen, and the Julius Center for Health Sciences and Primary Care, Utrecht University (D.E.G.), Utrecht, Netherlands.
  • Frans J. Kok
    From the Division of Human Nutrition, Wageningen University (J.E.N., B.E.S., F.J.K., J.M.G.), Wageningen, and the Julius Center for Health Sciences and Primary Care, Utrecht University (D.E.G.), Utrecht, Netherlands.
  • Diederick E. Grobbee
    From the Division of Human Nutrition, Wageningen University (J.E.N., B.E.S., F.J.K., J.M.G.), Wageningen, and the Julius Center for Health Sciences and Primary Care, Utrecht University (D.E.G.), Utrecht, Netherlands.
  • Johanna M. Geleijnse
    From the Division of Human Nutrition, Wageningen University (J.E.N., B.E.S., F.J.K., J.M.G.), Wageningen, and the Julius Center for Health Sciences and Primary Care, Utrecht University (D.E.G.), Utrecht, Netherlands.

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タイトル別名
  • A Meta-Analysis of Randomized Controlled Trials

抄録

<jats:p>Increased body weight is a strong risk factor for hypertension. A meta-analysis of randomized controlled trials was performed to estimate the effect of weight reduction on blood pressure overall and in population subgroups. Twenty-five randomized, controlled trials (comprising 34 strata) published between 1966 and 2002 with a total of 4874 participants were included. A random-effects model was used to account for heterogeneity among trials. A net weight reduction of −5.1 kg (95% confidence interval [CI], −6.03 to −4.25) by means of energy restriction, increased physical activity, or both reduced systolic blood pressure by −4.44 mm Hg (95% CI, −5.93 to −2.95) and diastolic blood pressure by −3.57 mm Hg (95% CI, −4.88 to −2.25). Blood pressure reductions were −1.05 mm Hg (95% CI, −1.43 to −0.66) systolic and −0.92 mm Hg (95% CI, −1.28 to −0.55) diastolic when expressed per kilogram of weight loss. As expected, significantly larger blood pressure reductions were observed in populations with an average weight loss >5 kg than in populations with less weight loss, both for systolic (−6.63 mm Hg [95% CI, −8.43 to −4.82] vs −2.70 mm Hg [95% CI, −4.59 to −0.81]) and diastolic (−5.12 mm Hg [95% CI, −6.48 to −3.75] vs −2.01 mm Hg [95% CI, −3.47 to −0.54]) blood pressure. The effect on diastolic blood pressure was significantly larger in populations taking antihypertensive drugs than in untreated populations (−5.31 mm Hg [95% CI, −6.64 to −3.99] vs −2.91 mm Hg [95% CI, −3.66 to −2.16]). This meta-analysis clearly shows that weight loss is important for the prevention and treatment of hypertension.</jats:p>

収録刊行物

  • Hypertension

    Hypertension 42 (5), 878-884, 2003-11

    Ovid Technologies (Wolters Kluwer Health)

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