Is Mild Cognitive Impairment Prodromal for Vascular Dementia Like Alzheimer’s Disease?

• John Stirling Meyer

  From the Departments of Neurology (J.S.M., G.X., M.H.C., M.Q.) and Family and Community Medicine (J.T.), Baylor College of Medicine, and Cerebrovascular Research (J.S.M., G.X., M.H.C., M.Q.) and Biostatistical Laboratories (J.T.), Veterans Administration Medical Center, Houston, Tex.

• Gelin Xu

  From the Departments of Neurology (J.S.M., G.X., M.H.C., M.Q.) and Family and Community Medicine (J.T.), Baylor College of Medicine, and Cerebrovascular Research (J.S.M., G.X., M.H.C., M.Q.) and Biostatistical Laboratories (J.T.), Veterans Administration Medical Center, Houston, Tex.

• John Thornby

  From the Departments of Neurology (J.S.M., G.X., M.H.C., M.Q.) and Family and Community Medicine (J.T.), Baylor College of Medicine, and Cerebrovascular Research (J.S.M., G.X., M.H.C., M.Q.) and Biostatistical Laboratories (J.T.), Veterans Administration Medical Center, Houston, Tex.

• Munir H. Chowdhury

  From the Departments of Neurology (J.S.M., G.X., M.H.C., M.Q.) and Family and Community Medicine (J.T.), Baylor College of Medicine, and Cerebrovascular Research (J.S.M., G.X., M.H.C., M.Q.) and Biostatistical Laboratories (J.T.), Veterans Administration Medical Center, Houston, Tex.

• Minh Quach

  From the Departments of Neurology (J.S.M., G.X., M.H.C., M.Q.) and Family and Community Medicine (J.T.), Baylor College of Medicine, and Cerebrovascular Research (J.S.M., G.X., M.H.C., M.Q.) and Biostatistical Laboratories (J.T.), Veterans Administration Medical Center, Houston, Tex.

抄録

Background and Purpose — Individuals with mild cognitive impairment (MCI) are at increased risk of Alzheimer’s disease (AD) and probably other forms of dementia. Some subtypes of vascular dementia (VaD) may possess minor neuropathological changes of AD that may contribute to cognitive impairments. It was posited that MCI, identified by criteria described here, might present as a prodrome for VaD and AD. Methods — Serial Mini-Mental State Examination was administered at 3- to 6-month intervals, and neuroimaging was performed annually. Subtle cognitive dysfunctions were weighted and measured according to MCI criteria defined here. Subjects identified with MCI were then followed up for an additional 3.88±3.01 years. Diagnoses of VaD and AD were made according to established criteria. Results — During 3.72±2.94 years of follow-up of the original normative subjects, 73 of 291 (25.1%) developed MCI. Of the 27 subjects who developed VaD, 15 (55.6%) had prodromal MCI. Of these, two thirds were subclassified as having small-vessel dementia. The remaining 12 patients with VaD (44.4%) were diagnosed directly from a cognitively normal status without preceding MCI. These were predominantly multi-infarct or strategic-infarct dementia (66.7%). An additional 35 MCI subjects (47.9%) developed AD. Both VaD and AD diagnosed after MCI prodromes manifested similar spectral domains of cognitive impairments, which included memory, during their MCI stages. Conclusions — In some VaD subtypes, particularly those caused by subcortical microvascular disease, dementia may be preceded by MCI, which has similar domains of cognitive impairment and a similar progressive course that may mimic AD.

収録刊行物

• Stroke

  Stroke 33 (8), 1981-1985, 2002-08

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Advanced and Specialized Nursing
• Cardiology and Cardiovascular Medicine
• Neurology (clinical)

詳細情報

• CRID: 1363951795304050688
• NII論文ID: 30022679543
• DOI: 10.1161/01.str.0000024432.34557.10
• ISSN: 15244628
• ISSN: 00392499
• Web Site: https://www.ahajournals.org/doi/full/10.1161/01.STR.0000024432.34557.10
• データソース種別:
  • Crossref
  • CiNii Articles