Atherosclerosis of Cerebral Arteries in Alzheimer Disease

DOI Web Site 被引用文献2件
  • Alex E. Roher
    From the Longtine Center for Molecular Biology and Genetics (A.E.R., C.E., A.R.) and The W. Harold Civin Laboratory of Neuropathology (T.G.B.), Sun Health Research Institute, Sun City, Ariz; and the Department of Microbiology (T.A.K.), Midwestern University, Glendale, Ariz.
  • Chera Esh
    From the Longtine Center for Molecular Biology and Genetics (A.E.R., C.E., A.R.) and The W. Harold Civin Laboratory of Neuropathology (T.G.B.), Sun Health Research Institute, Sun City, Ariz; and the Department of Microbiology (T.A.K.), Midwestern University, Glendale, Ariz.
  • Afroza Rahman
    From the Longtine Center for Molecular Biology and Genetics (A.E.R., C.E., A.R.) and The W. Harold Civin Laboratory of Neuropathology (T.G.B.), Sun Health Research Institute, Sun City, Ariz; and the Department of Microbiology (T.A.K.), Midwestern University, Glendale, Ariz.
  • Tyler A. Kokjohn
    From the Longtine Center for Molecular Biology and Genetics (A.E.R., C.E., A.R.) and The W. Harold Civin Laboratory of Neuropathology (T.G.B.), Sun Health Research Institute, Sun City, Ariz; and the Department of Microbiology (T.A.K.), Midwestern University, Glendale, Ariz.
  • Thomas G. Beach
    From the Longtine Center for Molecular Biology and Genetics (A.E.R., C.E., A.R.) and The W. Harold Civin Laboratory of Neuropathology (T.G.B.), Sun Health Research Institute, Sun City, Ariz; and the Department of Microbiology (T.A.K.), Midwestern University, Glendale, Ariz.

抄録

<jats:p>A growing body of evidence suggests that vascular disease underlies Alzheimer dementia. Atherosclerotic lesions in the circle of Willis and large leptomeningeal vessels were quantified and found to correlate with Alzheimer disease (AD) clinical diagnosis and neuropathology. We hypothesize that AD pathology is the complex end result of slowly evolving vascular disease and parenchymal lesions. Confirmation of a central role for vascular pathology in AD will suggest important treatment options and directions for additional interventions to stave off this dementia.</jats:p>

収録刊行物

  • Stroke

    Stroke 35 (11_suppl_1), 2623-2627, 2004-11

    Ovid Technologies (Wolters Kluwer Health)

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