Low-Dose Aspirin for Prevention of Stroke in Low-Risk Patients With Atrial Fibrillation
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- Hiroshi Sato
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Kinji Ishikawa
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Akira Kitabatake
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Satoshi Ogawa
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Yukio Maruyama
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Yoshiyuki Yokota
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Takaya Fukuyama
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Yoshinori Doi
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Seibu Mochizuki
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Tohru Izumi
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Noboru Takekoshi
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Kiyoshi Yoshida
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Katsuhiko Hiramori
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Hideki Origasa
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Shinichiro Uchiyama
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Masayasu Matsumoto
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Takenori Yamaguchi
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
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- Masatsugu Hori
- From the Department of Cardiovascular Medicine (H.S., M.H.) Osaka University Graduate School of Medicine, Suita, Japan; Department of Cardiology (K.I.), Kinki University School of Medicine, Osakasayama, Japan; Department of Cardiovascular Medicine (A.K.), Hokkaido University Graduate School of Medicine, Sapporo, Japan; Division of Cardiology (S.O.), Department of Medicine, Keio University School of Medicine, Tokyo, Japan; First Department of Internal Medicine (Y.M.), Fukushima Medical University,...
書誌事項
- タイトル別名
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- Japan Atrial Fibrillation Stroke Trial
抄録
<jats:p> <jats:bold> <jats:italic>Background and Purpose—</jats:italic> </jats:bold> Although the efficacy of anticoagulant therapy for primary prevention of stroke in patients with nonvalvular atrial fibrillation (NVAF) has been established, efficacy of antiplatelet therapy for low-risk patients is disputable in Japanese patients because of the frequent hemorrhagic complications. We examined the efficacy and safety of aspirin therapy in Japanese patients with NVAF in a prospective randomized multicenter trial. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods—</jats:italic> </jats:bold> Patients with NVAF were randomized to an aspirin group (aspirin at 150 to 200 mg per day) or a control group without antiplatelet or anticoagulant therapy. Primary end points included cardiovascular death, symptomatic brain infarction, or transient ischemic attack. </jats:p> <jats:p> <jats:bold> <jats:italic>Results—</jats:italic> </jats:bold> A total of 426 patients were randomized to aspirin group and 445 to no treatment. The trial was stopped earlier because there were 27 primary end point events (3.1% per year; 95% CI, 2.1% to 4.6% per year) in the aspirin group versus 23 (2.4% per year; 95% CI, 1.5% to 3.5% per year) in the control group, suggesting a low possibility of superiority of the aspirin treatment for prevention of the primary end point. In addition, treatment with aspirin caused a marginally increased risk of major bleeding (7 patients; 1.6%) compared with the control group (2 patients; 0.4%; Fisher exact test <jats:italic>P</jats:italic> =0.101). </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> For prevention of stroke in patients with NVAF, aspirin at 150 to 200 mg per day does not seem to be either effective or safe. Further prospective studies are needed to determine the best preventive therapy for cerebrovascular events in Japanese patients with NVAF. </jats:p>
収録刊行物
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- Stroke
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Stroke 37 (2), 447-451, 2006-02
Ovid Technologies (Wolters Kluwer Health)
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詳細情報 詳細情報について
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- CRID
- 1363107369153199872
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- NII論文ID
- 30022681425
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- ISSN
- 15244628
- 00392499
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- データソース種別
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- Crossref
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