Practical Management of Patients With Chronic Myeloid Leukemia Receiving Imatinib

DOI Web Site 被引用文献12件
  • Michael W.N. Deininger
    From the BMT/Leukemia Center, Oregon Health and Science University Cancer Institute, Portland, OR; Department of Haematology, The Medical School, University of Newcastle, Newcastle, UK; Novartis AG, Basel, Switzerland;
  • Stephen G. O’Brien
    From the BMT/Leukemia Center, Oregon Health and Science University Cancer Institute, Portland, OR; Department of Haematology, The Medical School, University of Newcastle, Newcastle, UK; Novartis AG, Basel, Switzerland;
  • John M. Ford
    From the BMT/Leukemia Center, Oregon Health and Science University Cancer Institute, Portland, OR; Department of Haematology, The Medical School, University of Newcastle, Newcastle, UK; Novartis AG, Basel, Switzerland;
  • Brian J. Druker
    From the BMT/Leukemia Center, Oregon Health and Science University Cancer Institute, Portland, OR; Department of Haematology, The Medical School, University of Newcastle, Newcastle, UK; Novartis AG, Basel, Switzerland;

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<jats:p> The introduction of imatinib, a specific inhibitor of the Bcr-Abl tyrosine kinase, has dramatically changed the management of chronic myeloid leukemia (CML). More than 10,000 patients worldwide have been treated with imatinib in clinical trials, and a large body of information has accumulated about the use of this drug. The purpose of this article is to review practical guidelines in regard to optimal dosing, monitoring, managing common side effects such as myelosuppression, and potential drug interactions. The treatment recommendations are intended to optimize therapy with imatinib while taking into account a patient’s specific circumstances. </jats:p>

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