C-Reactive Protein Genotypes Affect Baseline, but not Exercise Training–Induced Changes, in C-Reactive Protein Levels

• Thomas O. Obisesan

  From the Department of Kinesiology (T.O.O., D.A.P., S.J.P., J.M.H.), University of Maryland, College Park, Md; the Section of Geriatrics (T.O.O.), Department of Medicine, Howard University Hospital, Washington DC; Biochemistry of Aging Laboratory (C.L., T.P.), College of Medicine and Health and Human Performance, University of Florida, Gainesville, Fla; and the Department of Human Genetics (R.E.F.), University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pa.

• Christiaan Leeuwenburgh

  From the Department of Kinesiology (T.O.O., D.A.P., S.J.P., J.M.H.), University of Maryland, College Park, Md; the Section of Geriatrics (T.O.O.), Department of Medicine, Howard University Hospital, Washington DC; Biochemistry of Aging Laboratory (C.L., T.P.), College of Medicine and Health and Human Performance, University of Florida, Gainesville, Fla; and the Department of Human Genetics (R.E.F.), University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pa.

• Tracey Phillips

  From the Department of Kinesiology (T.O.O., D.A.P., S.J.P., J.M.H.), University of Maryland, College Park, Md; the Section of Geriatrics (T.O.O.), Department of Medicine, Howard University Hospital, Washington DC; Biochemistry of Aging Laboratory (C.L., T.P.), College of Medicine and Health and Human Performance, University of Florida, Gainesville, Fla; and the Department of Human Genetics (R.E.F.), University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pa.

• Robert E. Ferrell

  From the Department of Kinesiology (T.O.O., D.A.P., S.J.P., J.M.H.), University of Maryland, College Park, Md; the Section of Geriatrics (T.O.O.), Department of Medicine, Howard University Hospital, Washington DC; Biochemistry of Aging Laboratory (C.L., T.P.), College of Medicine and Health and Human Performance, University of Florida, Gainesville, Fla; and the Department of Human Genetics (R.E.F.), University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pa.

• Dana A. Phares

  From the Department of Kinesiology (T.O.O., D.A.P., S.J.P., J.M.H.), University of Maryland, College Park, Md; the Section of Geriatrics (T.O.O.), Department of Medicine, Howard University Hospital, Washington DC; Biochemistry of Aging Laboratory (C.L., T.P.), College of Medicine and Health and Human Performance, University of Florida, Gainesville, Fla; and the Department of Human Genetics (R.E.F.), University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pa.

• Steven J. Prior

  From the Department of Kinesiology (T.O.O., D.A.P., S.J.P., J.M.H.), University of Maryland, College Park, Md; the Section of Geriatrics (T.O.O.), Department of Medicine, Howard University Hospital, Washington DC; Biochemistry of Aging Laboratory (C.L., T.P.), College of Medicine and Health and Human Performance, University of Florida, Gainesville, Fla; and the Department of Human Genetics (R.E.F.), University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pa.

• James M. Hagberg

  From the Department of Kinesiology (T.O.O., D.A.P., S.J.P., J.M.H.), University of Maryland, College Park, Md; the Section of Geriatrics (T.O.O.), Department of Medicine, Howard University Hospital, Washington DC; Biochemistry of Aging Laboratory (C.L., T.P.), College of Medicine and Health and Human Performance, University of Florida, Gainesville, Fla; and the Department of Human Genetics (R.E.F.), University of Pittsburgh, Graduate School of Public Health, Pittsburgh, Pa.

抄録

Objective— The goal of this study is to determine whether C-reactive protein (CRP) gene variants affect baseline and training-induced changes in plasma CRP levels. Methods and Results— Sixty-three sedentary men and women aged 50 to 75 years old underwent baseline testing (V o max, body composition, CRP levels). They repeated these tests after 24 weeks of exercise training while on a low-fat diet. The CRP +219G/A variant significantly associated with CRP levels before and after training after accounting for the effects of demographic and biological variables. CRP −732A/G genotype was significantly related on a univariate basis to CRP levels after training. The CRP +29T/A variant did not affect CRP levels before or after training. In regression analyses, the +219 and −732 variants each had significant effects on CRP levels before and after training. Subjects homozygous for the common A/G −732/+219 haplotype exhibited the highest CRP levels, and having the rare allele at either site was associated with significantly lower CRP levels. CRP levels decreased significantly with training (−0.38±0.18 mg/L; P =0.03). However, none of the CRP variants was associated with the training-induced CRP changes. Conclusion— CRP +219G/A and −732A/G genotypes and haplotypes and exercise training appear to modulate CRP levels. However, training-induced CRP reductions appear to be independent of genotype at these loci.

収録刊行物

• Arteriosclerosis, Thrombosis, and Vascular Biology

  Arteriosclerosis, Thrombosis, and Vascular Biology 24 (10), 1874-1879, 2004-10

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Cardiology and Cardiovascular Medicine

詳細情報

• CRID: 1361137045516118400
• NII論文ID: 30023095110
• DOI: 10.1161/01.atv.0000140060.13203.22
• ISSN: 15244636
• ISSN: 10795642
• Web Site: https://www.ahajournals.org/doi/full/10.1161/01.ATV.0000140060.13203.22
• データソース種別:
  • Crossref
  • CiNii Articles