Melatonin effect on arachidonic acid metabolism to cyclooxygenase derivatives in human platelets

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<jats:p><jats:bold>Abstract: </jats:bold> The effect of melatonin on thrombin‐induced [<jats:sup>3</jats:sup>H]‐arachidonic acid (AA) metabolism to cyclooxygenase derivatives was determined in platelets obtained from normal volunteers at 0830 and 2030 h. Percent conversion of radioactive AA was generally greater at 2030 h than at 0830 h for every cyclooxygenase derivative analyzed. Micromolar or greater concentrations of melatonin decreased significantly the conversion of [<jats:sup>3</jats:sup>H]‐AA to prostaglandin (PG) F<jats:sub>2</jats:sub> and thromboxane (Tx) B2, and inhibited slightly the conversion to PGE<jats:sub>2</jats:sub> and PGD<jats:sub>2</jats:sub>. After preincubation of platelets with 1 mM imidazole, the melatonin inhibitory effect was significant for PGF<jats:sub>2</jats:sub> only. Melatonin (10<jats:sup>−6</jats:sup> M) showed a significant inhibitory influence on platelet ATP release induced by phorbol‐12 myristate‐13 acetate (PMA) at 2030 h, an effect inhibited by 1 mM aspirin. These results indicate that at pharmacological concentrations melatonin inhibits human platelet cyclooxygenase.</jats:p>

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