Discrepancy between PNMT presence and relative lack of adrenaline production in extra‐adrenal pheochromocytoma

• Hiroomi Funahashi

• Tsuneo Imai

• Yuji Tanaka

• Jun‐Ichi Tobinaga

• Masaki Wada

• Takako Matsuyama

• Kyosuke Tsukamura

• Fumio Yamada

• Hiroshi Takagi

• Tatsuhiko Narita

• Takashi Koshikawa

抄録

Among catecholamine synthesizing enzymes, phenylethanolamine‐N‐methyltransferase (PNMT) exists only in adrenal and extra‐adrenal pheochromoeytoma has been believed not to produce adrenaline. However, adrenaline production is clinically active in some extra‐adrenal cases. To investigate this controversy, the localization of catecholamine synthesizing enzymes was studied by immunohistochemical staining in extra‐adrenal and adrenal cases. The results showed that PNMT was expressed not only in many cases of adrenal pheochromocytoma, but also in extra‐adrenal pheochromocytoma. It is suspected that little adrenaline production in extra‐adrenal cases is attributable to a lack of a good environment for the activation of PNMT by a high concentration of glucocorticoids. © 1994 Wiley‐Liss, Inc.

収録刊行物

• Journal of Surgical Oncology

  Journal of Surgical Oncology 57 (3), 196-200, 1994-11

  Wiley

キーワード

• Oncology
• General Medicine
• Surgery

詳細情報

• CRID: 1363388846278390016
• NII論文ID: 30025879360
• DOI: 10.1002/jso.2930570312
• ISSN: 10969098
• ISSN: 00224790
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjso.2930570312
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/jso.2930570312
• データソース種別:
  • Crossref
  • CiNii Articles