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- Maria Sörhede Winzell
- Department of Medicine, Biomedical Center, Lund University, Lund, Sweden
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- Bo Ahrén
- Department of Medicine, Biomedical Center, Lund University, Lund, Sweden
抄録
<jats:p>This study characterizes the high-fat diet–fed mouse as a model for impaired glucose tolerance (IGT) and type 2 diabetes. Female C57BL/6J mice were fed a high-fat diet (58% energy by fat) or a normal diet (11% fat). Body weight was higher in mice fed the high-fat diet already after the first week, due to higher dietary intake in combination with lower metabolic efficiency. Circulating glucose increased after 1 week on high-fat diet and remained elevated at a level of ∼1 mmol/l throughout the 12-month study period. In contrast, circulating insulin increased progressively by time. Intravenous glucose challenge revealed a severely compromised insulin response in association with marked glucose intolerance already after 1 week. To illustrate the usefulness of this model for the development of new treatment, mice were fed an orally active inhibitor of dipeptidyl peptidase-IV (LAF237) in the drinking water (0.3 mg/ml) for 4 weeks. This normalized glucose tolerance, as judged by an oral glucose tolerance test, in association with augmented insulin secretion. We conclude that the high-fat diet–fed C57BL/6J mouse model is a robust model for IGT and early type 2 diabetes, which may be used for studies on pathophysiology and development of new treatment.</jats:p>
収録刊行物
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- Diabetes
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Diabetes 53 (suppl_3), S215-S219, 2004-12-01
American Diabetes Association
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詳細情報 詳細情報について
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- CRID
- 1360011143924746624
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- NII論文ID
- 30026271910
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- ISSN
- 1939327X
- 00121797
- http://id.crossref.org/issn/00121797
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- データソース種別
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- Crossref
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