Stiffness Indexes β of the Common Carotid and Femoral Arteries Are Associated With Insulin Resistance in NIDDM

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  • Masanori Emoto
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
  • Yoshiki Nishizawa
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
  • Takahiko Kawagishi
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
  • Kiyoshi Maekawa
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
  • Yoshikazu Hiura
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
  • Hiroyuki Kanda
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
  • Kyoko Izumotani
    Osaka Municipal Health Promotion Center Osaka, Japan
  • Tetsuo Shoji
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
  • Eiji Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
  • Masaaki Inaba
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
  • Yasuhisa Okuno
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan
  • Hirotoshi Morii
    Second Department of Internal Medicine, Osaka City University Medical School Osaka, Japan

Abstract

<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>To investigate the association between arterial wall stiffness indexes β of the common carotid artery (CCA) and the femoral artery (FA) and insulin resistance in NIDDM subjects in a cross-sectional study.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>We evaluated the arterial stiffness indexes β of CCA and FA using an ultrasonic phase-locked echo-tracking system in 60 NIDDM subjects attending the diabetes center in Osaka City University Hospital, compared with 120 ageand sex-matched control subjects. Insulin sensitivity indexes were evaluated using a euglycemic-hyperinsulinemic clamp.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>Stiffness indexes β of both CCA and FA were significantly higher in NIDDM subjects than in control subjects (CCA 18.1 ± 0.9 vs. 11.7 ± 0.3, respectively, P &lt; 0.001; FA 35.7 ± 2.3 vs. 23.7 ± 0.8, respectively, P &lt; 0.001). The mean insulin sensitivity index in NIDDM subjects was 4.69 ± 0.29 mg · kg−1 · min−1 · mU−1 · 1. The stiffness indexes β of both CCA and FA were inversely correlated with insulin sensitivity indexes (CCA r = −0.393, P = 0.002; FA r = −0.329, P = 0.010), as well as with age, duration of diabetes, and mean blood pressure. In stepwise multiple regression analyses, insulin sensitivity index and duration of diabetes were identified as significant independent variables for stiffness indexes 3 in both CCA and FA (CCA R2 = 0.249, P = 0.0003; FA R2 = 0.336, P &lt; 0.0001).</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Arterial stiffness indexes β of CCA and FA were associated with insulin resistance in NIDDM subjects.</jats:p> </jats:sec>

Journal

  • Diabetes Care

    Diabetes Care 21 (7), 1178-1182, 1998-07-01

    American Diabetes Association

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