HOMA-Estimated Insulin Resistance Is an Independent Predictor of Cardiovascular Disease in Type 2 Diabetic Subjects

DOI PDF 被引用文献9件
  • Enzo Bonora
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Gianni Formentini
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Francesco Calcaterra
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Simonetta Lombardi
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Franco Marini
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Luciano Zenari
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Francesca Saggiani
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Maurizio Poli
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Sandro Perbellini
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Andrea Raffaelli
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Vittorio Cacciatori
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Lorenza Santi
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Giovanni Targher
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Riccardo Bonadonna
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy
  • Michele Muggeo
    From the Endocrinology and Metabolic Diseases, University of Verona Medical School, Verona, Italy

抄録

<jats:p>OBJECTIVE—To evaluate whether homeostasis model assessment-estimated insulin resistance (HOMA-IR) is an independent predictor of cardiovascular disease (CVD) in type 2 diabetes.</jats:p> <jats:p>RESEARCH DESIGN AND METHODS—Conventional CVD risk factors (sex, age, smoking, plasma lipids, blood pressure, and metabolic control) and insulin resistance (estimated by HOMA) were evaluated at baseline in 1,326 patients with type 2 diabetes examined within the Verona Diabetes Complications Study. At baseline and after a mean follow-up of 4.5 years, CVD was assessed by medical history, physical examination, electrocardiography, and echo-Doppler of carotid and lower limb arteries. Death certificates and medical records of subjects who died during the follow-up were carefully scrutinized to identify cardiovascular deaths. In statistical analyses, CVD was an aggregate end point including both fatal and nonfatal coronary, cerebrovascular, and peripheral vascular disease as well as ischemic electrocardiographic abnormalities and vascular lesions identified by echo-Doppler.</jats:p> <jats:p>RESULTS—At baseline, 441 subjects were coded positive for CVD (prevalent cases). Incident cases numbered 126. Multiple logistic regression analyses showed that, along with sex, age, smoking, HDL/total cholesterol ratio, and hypertension, HOMA-IR was an independent predictor of both prevalent and incident CVD. A 1-unit increase in (log)HOMA-IR value was associated with an odds ratio for prevalent CVD at baseline of 1.31 (95% CI 1.10–1.56, P = 0.002) and for incident CVD during follow-up of 1.56 (95% CI 1.14–2.12, P &lt; 0.001).</jats:p> <jats:p>CONCLUSIONS—HOMA-IR is an independent predictor of CVD in type 2 diabetes. The improvement of insulin resistance might have beneficial effects not only on glucose control but also on CVD in patients with type 2 diabetes.</jats:p>

収録刊行物

  • Diabetes Care

    Diabetes Care 25 (7), 1135-1141, 2002-07-01

    American Diabetes Association

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