Effects of Trp64Arg Mutation in the β3-Adrenergic Receptor Gene on Weight Loss, Body Fat Distribution, Glycemic Control, and Insulin Resistance in Obese Type 2 Diabetic Patients

• Naoki Sakane

  Department of Internal Medicine, Kyoto Prefectural University of Medicine, Ayabe Municipal Hospital Kyoto, Japan

• Toshihide Yoshida

  Department of Internal Medicine, Kyoto Prefectural University of Medicine, Ayabe Municipal Hospital Kyoto, Japan

• Tsunekazu Umekawa

  Department of Internal Medicine, Kyoto Prefectural University of Medicine, Ayabe Municipal Hospital Kyoto, Japan

• Akinori Kogure

  Department of Internal Medicine, Kyoto Prefectural University of Medicine, Ayabe Municipal Hospital Kyoto, Japan

• Yasuto Takakura

  Department of Internal Medicine, Kyoto Prefectural University of Medicine, Ayabe Municipal Hospital Kyoto, Japan

• Motoharu Kondo

  Department of Internal Medicine, Kyoto Prefectural University of Medicine, Ayabe Municipal Hospital Kyoto, Japan

抄録

To investigate the effects of Trp64Arg mutation in the β3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients. We measured body weight, waist-to-hip ratio (WHR), adjusted resting metabolic rate, fasting blood glucose, fasting serum insulin levels, insulin resistance index (fasting glucose × fasting insulin/22.5), and HbA1c levels before and after 12 weeks of obesity treatment in 61 obese women with type 2 diabetes. The Mval polymorphism of the β3-adrenergic receptor gene was determined by polymerase chain reaction-restriction fragment length polymorphism analysis. Of obese type 2 diabetic patients, those with the mutation (n = 24) had a higher WHR (P < 0.001), a lower adjusted metabolic rate, and higher blood glucose levels, serum insulin levels, insulin resistance index (P < 0.001), and HbA1c levels (P = 0.016). Furthermore, patients with the mutation had smaller decreases in body weight, WHR, insulin resistance index, and HbA1c levels after the weight-loss program compared with patients without the mutation (n = 37), even though food intake, exercise, and serum thyroid hormone levels were similar in both groups. These present findings show that the Trp64Arg allele of the β3-adrenergic receptor gene may predict difficulty in losing body weight, lowering WHR, and improving glycemic control and insulin resistance in obese patients with type 2 diabetes.

収録刊行物

• Diabetes Care

  Diabetes Care 20 (12), 1887-1890, 1997-12-01

  American Diabetes Association

キーワード

• Advanced and Specialized Nursing
• Endocrinology, Diabetes and Metabolism
• Internal Medicine

詳細情報

• CRID: 1362825894341267328
• NII論文ID: 30026279703
• DOI: 10.2337/diacare.20.12.1887
• ISSN: 19355548
• ISSN: 01495992
• ISSN: http://id.crossref.org/issn/01495992
• Web Site: https://diabetesjournals.org/care/article-pdf/20/12/1887/583777/20-12-1887.pdf
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  • CiNii Articles