Combination Insulin-Sulfonylurea Therapy

• Harold E Lebovitz

  Department of Medicine, Division of Endocrinology, State University of New York Health Science Center at Brooklyn Brooklyn, New York

• RoseMarie Pasmantier

  Department of Medicine, Division of Endocrinology, State University of New York Health Science Center at Brooklyn Brooklyn, New York

抄録

Combination sulfonylurea-insulin therapy for patients with diabetes mellitus has been evaluated by numerous investigators with various experimental designs. Much of the data are conflicting, and clear conclusions do not seem justified. Insulin-sulfonylurea therapy is probably not clinically useful in most patients with insulindependent diabetes mellitus. Most non-insulindependent diabetic (NIDOM) patients are also unlikely to have meaningful improvement in glycemic regulation on insulin-sulfonylurea therapy. A subset of NIDDM patients who are mildly to moderately obese, have adequate endogenous insulin secretory reserve, and are in poor glycemic regulation (fasting plasma glucose >11mM and/or HbA1 >10%), despite twice-daily insulin administration of >70 U/day, may show significant improvement of glycemic regulation and/or decreases in insulin daily dose on insulin-sulfonylurea therapy. The mechanisms by which insulin-sulfonylurea therapy improves glycemic regulation and decreases insulin requirements involve an increase in endogenous insulin secretion and possibly some extrapancreatic actions of the sulfonylureas on muscle and liver.

収録刊行物

• Diabetes Care

  Diabetes Care 13 (6), 667-675, 1990-06-01

  American Diabetes Association

キーワード

• Advanced and Specialized Nursing
• Endocrinology, Diabetes and Metabolism
• Internal Medicine

詳細情報

• CRID: 1361699995331512448
• NII論文ID: 30026281535
• DOI: 10.2337/diacare.13.6.667
• ISSN: 19355548
• ISSN: 01495992
• Web Site: https://diabetesjournals.org/care/article-pdf/13/6/667/439441/13-6-667.pdf
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