How Fibroblasts and Giant Cells Encapsulate Implants: Considerations in Design of Glucose Sensors

• Stephen C Woodward

  Department of Pathology, University of Utah, and the Veterans Administration Medical Center Salt Lake City, Utah

抄録

Implanted sensors ideally should measure glucose in an extracellular fluid that closely reflects changing concentrations of glucose in plasma; yet fibroblasts, fibrocytes, collagen, and giant cells provide adherent, impermeable, avascular barriers when they encapsulate irregularly-surfaced implants. Thus, sensor design should seek to provide a surface configuration that is without anchoring points for encapsulating cells, a consideration not unlike those posed in developing a nonthrombogenic surface. Examples of well-characterized host responses to various surface configurations are provided to illustrate how surface design features can avoid evoking a barrier of collagen as the host response to the sensor.

収録刊行物

• Diabetes Care

  Diabetes Care 5 (3), 278-281, 1982-05-01

  American Diabetes Association

キーワード

• Advanced and Specialized Nursing
• Endocrinology, Diabetes and Metabolism
• Internal Medicine

詳細情報

• CRID: 1360292620971033984
• NII論文ID: 30026282429
• NII書誌ID: AA00160920
• DOI: 10.2337/diacare.5.3.278
• ISSN: 19355548
• ISSN: 01495992
• ISSN: http://id.crossref.org/issn/01495992
• Web Site: https://diabetesjournals.org/care/article-pdf/5/3/278/550460/5-3-278.pdf
• データソース種別:
  • Crossref
  • CiNii Articles