Development of a Miniaturized Glucose Monitoring System by Combining a Needle-Type Glucose Sensor With Microdialysis Sampling Method: Long-term subcutaneous tissue glucose monitoring in ambulatory diabetic patients

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  • Yasuhiro Hashiguchi
    Department of Metabolic Medicine, Kumamoto University School of Medicine Kumamoto, Japan
  • Michiharu Sakakida
    Department of Metabolic Medicine, Kumamoto University School of Medicine Kumamoto, Japan
  • Kenro Nishida
    Department of Metabolic Medicine, Kumamoto University School of Medicine Kumamoto, Japan
  • Takero Uemura
    Department of Metabolic Medicine, Kumamoto University School of Medicine Kumamoto, Japan
  • Ken-Ichiro Kajiwara
    Department of Metabolic Medicine, Kumamoto University School of Medicine Kumamoto, Japan
  • Motoaki Shichiri
    Department of Metabolic Medicine, Kumamoto University School of Medicine Kumamoto, Japan

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<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>To develop a reliable and practical glucose monitoring system by combining a needle-type glucose sensor with a microdialysis sampling technique for long-term subcutaneous tissue glucose measurements.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>A microdialysis Cuprophan hollowfiber probe (inner diameter, 0.20 mm; length, 15 mm) was perfused with isotonic saline solution (120 μl/h) and glucose concentrations in the dialysate were measured by a needle-type glucose sensor extracorporeally. This system was tested both in vitro and in vivo. Subcutaneous tissue glucose concentrations were then monitored continuously in 5 healthy and 8 diabetic volunteers for 7 to 8 days. A hollow-fiber probe was inserted into the abdominal subcutaneous tissue.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>This monitoring system achieved excellent results in vitro. Subcutaneous tissue glucose concentrations were measured in a wide range from 1.7 to &gt;027.8 mM glucose, with a time delay of 6.9 ±1.2 min associated with a rise in glucose and 8.8 ±1.6 min with a fall in the glucose level (means ± SE). The overall correlation between subcutaneous tissue (Y) and blood (X) glucose concentration was Y = 1.08X ± 0.19 (r = 0.99). The subcutaneous tissue glucose concentration could be monitored precisely for 4 days without any in vivo calibrations and for 7 days by introducing in vivo calibrations.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>Glycemic excursions could be monitored precisely in the subcutaneous tissue by this microdialysis sampling method with a needle-type glucose sensor in ambulatory diabetic patients.</jats:p> </jats:sec>

収録刊行物

  • Diabetes Care

    Diabetes Care 17 (5), 387-396, 1994-05-01

    American Diabetes Association

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