Decreased release of lipoprotein lipase is associated with vascular endothelial damage in NIDDM patients with microalbuminuria.

• K Kashiwazaki

  First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

• T Hirano

  First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

• G Yoshino

  First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

• M Kurokawa

  First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

• H Tajima

  First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

• M Adachi

  First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.

抄録

OBJECTIVE: To explore mechanisms for hypertriglyceridemia in diabetic patients with microalbuminuria, we examined an association between heparin-releasable lipoprotein lipase (LPL) and the von Willebrand factor (vWF), based on the hypothesis that LPL bound to endothelium is decreased by generalized endothelial damage. RESEARCH DESIGN AND METHODS: A total of 37 NIDDM patients with microalbuminuria and 69 patients with normoalbuminuria were studied. Plasma LPL mass in post-heparin plasma and plasma vWF antigen were quantified by sandwich-enzyme immunoassay and enzyme-linked immunosorbent assay, respectively. RESULTS: The NIDDM patients with microalbuminuria had higher plasma triglyceride (TG) and lower HDL cholesterol concentrations compared with the patients with normoalbuminuria. Heparin-releasable LPL mass was significantly lower in the microalbuminuric than in the normoalbuminuric subjects. Plasma level of vWF, a marker for endothelial damage, was significantly increased in microalbuminuric subjects compared with their normoalbuminuric counterparts. The LPL mass was inversely correlated with plasma vWF level at a high correlation coefficient value. The LPL mass was inversely related to TG and positively to HDL cholesterol concentrations. CONCLUSIONS: These results suggest that widespread endothelial damage occurred in NIDDM patients with microalbuminuria, thereby LPL moiety bound to the endothelium is decreased, which results in an impaired catabolism of TG-rich lipoproteins.

収録刊行物

• Diabetes Care

  Diabetes Care 21 (11), 2016-2020, 1998-11-01

  American Diabetes Association

キーワード

• Advanced and Specialized Nursing
• Endocrinology, Diabetes and Metabolism
• Internal Medicine

詳細情報

• CRID: 1362825895063975424
• NII論文ID: 30026283817
• NII書誌ID: AA00160920
• DOI: 10.2337/diacare.21.11.2016
• ISSN: 19355548
• ISSN: 01495992
• Web Site: https://diabetesjournals.org/care/article-pdf/21/11/2016/447475/9802760.pdf
• データソース種別:
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  • CiNii Articles