Decreased Coagulability Has No Clinically Relevant Effect on Atherogenesis

• A. Šrámek

  From the Departments of Clinical Epidemiology (A.S., F.R.R.), and Radiology (J.H.C.R.) and the Hemostasis and Thrombosis Research Center (F.R.R.), Leiden University Medical Center, Leiden; and the Department of Hematology (W.B.J.G.), Leyenburg Hospital, The Hague, the Netherlands.

• J.H.C. Reiber

  From the Departments of Clinical Epidemiology (A.S., F.R.R.), and Radiology (J.H.C.R.) and the Hemostasis and Thrombosis Research Center (F.R.R.), Leiden University Medical Center, Leiden; and the Department of Hematology (W.B.J.G.), Leyenburg Hospital, The Hague, the Netherlands.

• W.B.J. Gerrits

  From the Departments of Clinical Epidemiology (A.S., F.R.R.), and Radiology (J.H.C.R.) and the Hemostasis and Thrombosis Research Center (F.R.R.), Leiden University Medical Center, Leiden; and the Department of Hematology (W.B.J.G.), Leyenburg Hospital, The Hague, the Netherlands.

• F.R. Rosendaal

  From the Departments of Clinical Epidemiology (A.S., F.R.R.), and Radiology (J.H.C.R.) and the Hemostasis and Thrombosis Research Center (F.R.R.), Leiden University Medical Center, Leiden; and the Department of Hematology (W.B.J.G.), Leyenburg Hospital, The Hague, the Netherlands.

書誌事項

タイトル別名

• Observations in Individuals With a Hereditary Bleeding Tendency

抄録

Background Hemostasis affects ischemic cardiovascular disease through its role in formation of occluding arterial thrombi. Several studies suggest that hemostasis also might play a role in atherogenesis. We investigated whether individuals with an inherited bleeding tendency are protected against development of atherosclerosis. Methods and Results A total of 76 individuals with an inherited bleeding tendency (hemophilia and von Willebrand disease) and 142 healthy controls were included in the present study. Early atherosclerotic vessel-wall changes were quantified by measurement of intima-media thickness in the carotid and femoral arteries by B-mode ultrasonography. To validate intima-media thickness measurements, measurements also were performed in 77 individuals with clinically proven atherosclerosis and in 34 healthy, age-matched controls. A large difference in intima-media thickness was found between individuals with proven atherosclerosis and healthy controls, in particular for the femoral artery (difference for carotid artery, 0.16 mm; femoral artery, 0.53 mm). Comparison between patients with a bleeding tendency and healthy controls showed only minimally reduced intima-media in femoral artery in individuals with a bleeding tendency (adjusted difference, −0.078 mm; 95% CI, −0.17 to 0.018 mm). Subgroup analysis revealed that in subjects with moderate to severe hemophilia, vessel walls were thinnest (adjusted difference, −0.10 mm; 95% CI, −0.27 to 0.061 mm). Conclusions Hypocoagulability caused by hemophilia or von Willebrand disease has at most a limited effect on atherogenesis.

収録刊行物

• Circulation

  Circulation 104 (7), 762-767, 2001-08-14

  Ovid Technologies (Wolters Kluwer Health)

キーワード

• Physiology (medical)
• Cardiology and Cardiovascular Medicine

詳細情報

• CRID: 1363388844921406336
• NII論文ID: 30029738806
• DOI: 10.1161/hc3501.094232
• ISSN: 15244539
• ISSN: 00097322
• Web Site: https://www.ahajournals.org/doi/full/10.1161/hc3501.094232
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