High Prevalence of Significant Heart Valve Lesions in Patients with the 'Primary' Antiphospholipid Syndrome
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- Ricard Cervera
- Lupus Arthritis Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK
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- Munther A. Khamashta
- Lupus Arthritis Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK
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- Josep Font
- Systemic Autoimmune Diseases Research Unit, Departments of Internal Medicine, Hospital, Clinic, Barcelona, Spain
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- Pedro A. Reyes
- Department of Immunology, Instituto Nacional de Cardiologia, Mexico DF. Mexico
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- João L. Vianna
- Lupus Arthritis Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK
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- Alfons López-Soto
- Systemic Autoimmune Diseases Research Unit, Departments of Internal Medicine, Hospital, Clinic, Barcelona, Spain
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- Mary-Carmen Amigo
- Department of Rheumatology, Instituto Nacional de Cardiologia, Mexico. DF. Mexico
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- Ronald A. Asherson
- Lupus Arthritis Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK
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- Manuel Azqueta
- Department of Cardiology, Hospital Clinic, Barcelona, Spain
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- Carles Paré
- Department of Cardiology, Hospital Clinic, Barcelona, Spain
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- Jesús Vargas
- Department of Echocardiography, Instituto Nacional de Cardiología, Mexico DF. Mexico
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- Angel Romero
- Department of Echocardiography, Instituto Nacional de Cardiología, Mexico DF. Mexico
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- Miguel Ingelmo
- Systemic Autoimmune Diseases Research Unit, Departments of Internal Medicine, Hospital, Clinic, Barcelona, Spain
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- Graham R.V. Hughes
- Lupus Arthritis Research Unit, Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK
Abstract
<jats:p> A prospective echocardiographic study was carried out on 55 patients with the recently described 'primary' antiphospholipid syndrome derived from three university medical centres. The prevalence of valvular lesions in patients with this syndrome was 38% compared with 4% in a control group of 55 healthy volunteers (P < 0.001). Mean age of patients with valve was 42 ± 12 years and of those without, 30 ± 10 years (P < 0.05). One patient had a morphologic echocardiographic pattern suggestive of non-infective verrucous mitral endocarditis. Twenty patients had a two-dimensional or Doppler echocardiographic pattern of significant valvular dysfunction —either regurgitation or stenosis—without evidence of vegetations. Mitral and aortic regurgitation were the most common lesions in these patients. During follow-up of patients with valvular disease, haemodynamically significant clinical valve disease developed in four and surgery was required in one. Eleven patients had cerebrovascular occlusions. Thus, valvular heart disease, particularly affecting the mitral and aortic valves, is common in patients with the 'primary' antiphospholipid syndrome, especially in. those over 40 years old. </jats:p>
Journal
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- Lupus
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Lupus 1 (1), 43-47, 1991-11
SAGE Publications
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Keywords
Details 詳細情報について
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- CRID
- 1362544418835860864
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- NII Article ID
- 30030769684
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- ISSN
- 14770962
- 09612033
- http://id.crossref.org/issn/09612033
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- Data Source
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- Crossref
- CiNii Articles