Frequency, clinical and laboratory features of thyroiditis in girls with Turner's syndrome

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<jats:p>A total of 478 patients, mean age 15.5 (3.6‐25.3) years, suffering from Turner's syndrome, were studied in order to determine the frequency of autoimmune thyroiditis, which is defined as the presence of antithyroid antibodies (AT‐Ab) and typical ultrasound findings. We found 106 (22.2%) patients positive for AT‐Ab and of those 49 (10%) also had positive ultrasound findings, and were therefore considered to be affected by thyroiditis. This frequency is significantly higher <jats:italic>(p <</jats:italic> 0.001) than that seen in the normal population. Goitre was detected on clinical examination in only 16 (33%) and by ultrasound in 19 (39%) patients. Hormonal evaluation showed that 17 patients were euthyroid, 27 had compensated hypothyroidism, 2 were hypothyroid and 3 were in a hyperthyroid phase. Clinical signs or symptoms of hypothyroidism were absent in all hypothyroid patients. In patients with thyroiditis, neither a higher frequency of malformations and autoimmune diseases nor a correlation with karyotype, oestrogens or growth hormone therapy was found.<jats:italic>Antithyroid antibodies, thyroiditis, thyroid hormones, thyroid ultrasound, Turner's syndrome</jats:italic></jats:p><jats:p> <jats:italic>G Radetti, Department of Paediatrics, Regional Hospital of Bolzano, via L Boehler 5, 39100 Bolzano, Italy</jats:italic> </jats:p>

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