Brasilicardin A; a New Terpenoid Antibiotic Produced by Nocardia brasiliensis.

• Komaki Hisayuki

• Nemoto Akira

• Tanaka Yasushi

• Yazawa Katsukiyo

• Tojo Takashi

• Takagi Hiroaki

• Kadowaki Kiyoshi

• Mikami Yuzuru

• Shigemori Hideyuki

• Kobayashi Jun-ichi

抄録

Our recent search for bioactive compounds from pathogenic Nocardia resulted in the isolation of a new antibiotic, brasilicardin A, from Nocardia brasiliensis IFM 0406, a clinical isolate from a lung nocardiosis patient. Brasilicardin A is a novel tricyclic diterpenoid containing an amino acid moiety, 3-hydroxybenzoate, a rhamnose and an N-acetylglucosamine unit. The antibiotic exhibited immunosuppressive activity in a mouse mixed lymphocyte reaction (MLR) assay system and its IC₅₀ value was 0.057 μg/ml. Its immunosuppressive mechanism was considered to be different from that of the reference drug, cyclosporin A (CyA), because brasilicardin A has no inhibitory activity against IL-2 production in mouse MLR assay. Also new bioactive substances which were recently isolated by our research groups from pathogenic Nocardia are reviewed.

収録刊行物

• 日本放線菌学会誌

  日本放線菌学会誌 12 (2), 92-96, 1998

  日本放線菌学会

キーワード

• General Medicine

詳細情報

• CRID: 1390001204701120640
• NII論文ID: 130004487479
• NII論文ID: 30035524499
• NII論文ID: 10008262961
• NII書誌ID: AN10080091
• DOI: 10.3209/saj.12_92
• COI: 1:CAS:528:DyaK1MXitF2lur0%3D
• ISSN: 18816371
• ISSN: 09145818
• NDL書誌ID: 3070604
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3070604
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可