Bronchoalveolar Lavage as a Possible Cause of Acute Exacerbation in Idiopathic Pulmonary Fibrosis Patients.
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- HIWATARI NANAKO
- The First Department of Internal Medicine, Tohoku University School of Medicine
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- SHIMURA SANAE
- The First Department of Internal Medicine, Tohoku University School of Medicine
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- TAKISHIMA TAMOTSU
- The First Department of Internal Medicine, Tohoku University School of Medicine
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- SHIRATO KUNIO
- The First Department of Internal Medicine, Tohoku University School of Medicine
抄録
HIWATARI, N., SHIMURA, S., TAKISHIMA, T. and SHIRATO, K. Bronchoalveolar Lavage as a Possible Cause of Acute Exacerbation in Idiopathic Pulmonary Fibrosis Patients. Tohoku J. Exp. Med., 1994, 174 (4), 379-386 - In the past 13 years (1980 to 1992), bronchoalveolar lavage (BAL) was performed on 124 idiopathic pulmonary fibrosis (IPF) patients (29 F and 95M, 60±1 years, mean± S.E.) at Tohoku University Clinic and Hospital. Among them, three patients showed acute exacerbation immediately after BAL and died of progressive respiratory failure after 2.5 weeks, 2 months and 3.5 months, respectively, despite intensive care. They were all older patients (79, 74 and 66 years old) and we failed to find any evidence of viral, bacterial or fungus infections either before or after BAL in blood, sputum or BAL fluid samples. Further, all autopsied lungs showed interstitial pneumonia and fibrosis and no evidence of infectious diseases. In contrast, no progressive deteriorations after BAL were observed in 282 patients (122 F and 160M, 48±1 years old) with other pulmonary diseases (sarcoidosis, bronchial asthma, collagen diseases and other interstitial lung diseases), who received BAL during the same period. This suggests that BAL itself sometimes induces a progressive degeneration in IPF patients, especially in older patients.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 174 (4), 379-386, 1994
東北ジャーナル刊行会