A new type of congenital dysfibrinogenaemia with defective fibrin lysis—Dusard syndrome: possible relation to thrombosis

DOI Web Site Web Site 被引用文献3件

この論文をさがす

抄録

<jats:p><jats:bold>S<jats:sc>ummary</jats:sc>. </jats:bold> Congenital dysfibrinogenaemia is described in three members of a family presenting with recurrent thrombosis and in two other young members not yet affected. An abnormality in the polymerization of fibrin monomers was noted. In addition, the pathological fibrin clots were found to be less sensitive to degradation by a post venous occlusion euglobulin solution than normal fibrin. After fibrin clot incubation with lys‐plasminogen at different concentrations, the biological activity of plasminogen in patient fibrin clot on S 2251 after SK‐addition, was less than that observed with normal fibrin. It is speculated that defective <jats:italic>in vivo</jats:italic> thrombolysis might explain the recurrent thrombosis observed in this family. This finding represents a new concept in understanding thromboembolic diseases.</jats:p>

収録刊行物

被引用文献 (3)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ