Clinical and laboratory features of <i>de novo</i> acute myeloid leukaemia with trilineage myelodysplasia

• F. Brito‐Babapulle

• D. Catovsky

• D. A. G. Galton

抄録

Primary myelodysplastic syndromes progress to acute myeloid leukaemia (AML) in about 30% of cases. We have sought evidence of pre‐existing trilineage myelodysplasia (TMDS) using the FAB criteria (1982) in 160 consecutive cases of primary de novo AML. TMDS was found in 24 cases (15%) including two of 33 cases of Ml (6%), four of 40 cases of M2 (10%), none of 18 cases of M3, five of 31 cases of M4 (15%), six of 30 cases of M5 (20%), all of six cases of M6 and one of two cases of M7. The median presentation bone‐marrow blast‐cell count in the 24 AML/TMDS cases was 53% (30–90%) and 82% (45–100%) in the 136 cases of AML without TMDS. 60% of the AML/TMDS bone‐marrow aspirates contained fewer than 60% of blasts compared with only 11% of those from AML without TMDS ( P <0.001). In AML the occurrence of symptomatic cytopenias when the marrow blast‐cell count is below 60% and the peripheral blood blast‐cell count is below 20% is highly correlated with dysplastic haemopoiesis ( P <0.001).

収録刊行物

• British Journal of Haematology

  British Journal of Haematology 66 (4), 445-450, 1987-08

  Wiley

キーワード

• Hematology

詳細情報

• CRID: 1361981471135472000
• NII論文ID: 30035647393
• DOI: 10.1111/j.1365-2141.1987.tb01325.x
• ISSN: 13652141
• ISSN: 00071048
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2141.1987.tb01325.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2141.1987.tb01325.x
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