Iatrogenic Creutzfeldt—Jakob disease in three growth hormone recipients: a neuropathological study

• T. Billette de Villemeur

• A. Gelot

• J. P. Deslys

• D. Dormont

• Ch. Duyckaerts

• L. Jardin

• J. Denni

• O. Robain

抄録

Since 1985, several cases of Creutzfeldt–Jakob disease, occurring after a treatment by human cadaveric hormone have been reported. Three new iatrogenic cases observed in French patients (two children and one young adult) are described here. Neuropathological study displayed the classical aspects of previously reported sporadic cases of Creutzfeldt–Jakob disease in adults, including severe cortical spongiform change with numerous vacuoles within neuronal dendrites, diffuse astrogliosis and neuronal loss. In addition, the iatrogenic cases described here included two more unusual points: (i) they were homozygotic for the PrP gene on codon 129 and therefore a genetic predisposition could be suspected; (ii) numerous kuru plaques were scattered in the cerebral cortex, the subcortical white matter and in the cerebellar cortex. They were decorated with a PrP monoclonal antibody, but not with a βA 4 antibody. This last point underlines the similarities between iatrogenic Creutzfeldt–Jakob disease and kuru.

収録刊行物

• Neuropathology and Applied Neurobiology

  Neuropathology and Applied Neurobiology 20 (2), 111-117, 1994-04

  Wiley

キーワード

• Physiology (medical)
• Neurology (clinical)
• Neurology
• Histology
• Pathology and Forensic Medicine

詳細情報

• CRID: 1361137045138578176
• NII論文ID: 30037278915
• DOI: 10.1111/j.1365-2990.1994.tb01169.x
• ISSN: 13652990
• ISSN: 03051846
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2990.1994.tb01169.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2990.1994.tb01169.x
• データソース種別:
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  • CiNii Articles