LONG-TERM EXPERIMENT OF MAXIMAL NON-CARCINOGENIC DOSE OF DIMETHYLNITROSAMINE FOR CARCINOGENESIS IN RATS
書誌事項
- タイトル別名
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- Long Term Experiment of Maximal Non Car
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Studies were made on the maximal non-carcinogenic dose of dimethylnitrosamine (DMN) in rats. Groups of Wistar strain rats of both sexes, 6 weeks old, were given standard diet without DMN (group 1), or containing 0.1ppm DMN (group 2), 1.0ppm DMN (group 3), or 10ppm DMN (group 4) for 96 weeks and then sacrificed for hematological, serum-biochemical, and histopathological examinations.<br>After 96 weeks, the weights of the body and main organs in the different groups were not significantly different. The leucocyte count and blood urea-nitrogen (BUN) in group 4 were slightly increased, but other serum findings were not significantly different in different groups.<br>Hepatocellular carcinomas were found in group 3 (1 male and 3 females), but not in group 2. Hemangioendotheliomas of the liver, adrenal adenomas, pituitary adenomas, interstitial cell tumors of the testis, ovarian tumors, and leukemia were also found. Pyelonephritis was found in both experimental and control animals, but no kidney tumors developed with these dose levels of DMN.<br>These results show that on long-term oral administration to rats, 1.0ppm DMN is the minimum carcinogenic dose, while a level of about 0.1ppm DMN is non-carcinogenic.
収録刊行物
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 70 (4), 549-558, 1979
日本癌学会
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詳細情報 詳細情報について
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- CRID
- 1390282680506835584
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- NII論文ID
- 130006409933
- 40000529381
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- NII書誌ID
- AN00045888
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- NDL書誌ID
- 2092646
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- ISSN
- 0016450X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可