幼若ラットの口蓋における各種手術創の治癒過程に関する組織学的ならびに走査電子顕微鏡的研究

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  • Histological and Scanning Electron Microscopic Studies on the Healing Process of Various Surgical Wounds on the Palate in Young Rats
  • ヨウジャク ラット ノ コウガイ ニ オケル カクシュ シュジュツ ソウ ノ

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The healing process of various palatal wounds according to palatoplasty was studied for up to 12 weeks postoperatively in young rats operated upon at 3 weeks of age, using macroscopical, microscopical and scanning electron microscopical observations. In Group I with the cutting of palatal neurovascular bundle, few changes were seen histologically or scanning electron microscopically. In Groups II-IV （II ; elevation of mucoperiosteum, III ; flap formation of mucoperiosteum, IV ; excision of mucosa）, with the preservation of the periosteum, obscure periosteum and degenerated bone were seen histologically, and resorbed changes were seen by scanning electron microscopy, in the early stage after operation. Fourteen days postoperatively, histological and scanning electron microscopic findings were similar to those on the unoperated side, that is to say, periosteal ossification was restored.In Group V with the excision of mucoperiosteum, histologically, sequestered bone was seen in the early stage after operation, a layer of osteogenic cells appearing on the palatal surface of the bone at 14 days after operation. Following the development of submucosal scar tissue, the layer began to become obscure, and fibrous conjunction between bone and scar tissue was seen without distinct periosteum 56 days postoperatively. Scanning electron microscopic findings were unique in this group. Lack of blood vessel holes and osteocyte lacunae, irregularity of the bone surface and adherence of collagen fiber to the bone were seen at 84 days postoperatively, with no periosteal ossification eventually being noted. From these findings, it can be stated that when the periosteum was preserved by operation on the palate, damage to bone was slight and periosteal new bone formation was restored. When mucoperiosteum was excised, however, damage to bone was marked, and regeneration of bone and perionsteum was prevented. It is suggested that this was caused by decrease in vascularization following the development of submucosal scar tissue.

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