紫外線照射によるヒト単球/マクロファージ様細胞致死に及ぼすタマネギ色素の抑制作用

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タイトル別名
  • Effect of Onion Pigments on the Killing Effect of Ultraviolet Irradiation toward Human Monocyte or Macrophage-like Cells.
  • 紫外線照射によるヒト単球/マクロファージ様細胞致死に及ぼすタマネギ色素の抑制作用〔英文〕
  • シガイセン ショウシャ ニ ヨル ヒト タンキュウ マクロファージヨウ サイボ

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The effect of 11 kinds of natural pigments derived from beet, berry, beta-carotene, chlorophyll, corn, gardenia blue, monascus, onion, paprika, red cabbage and safflower yellow on the killing effect of ultraviolet (UV) irradiation toward a human histiocytic lymphoma (U-937), a U-937-derived macrophage (U-M) and a human promyelocytic leukemia (HL-60) cell line was examined. U-937 cells were more insensitive to UV irradiation than U-M and HL-60 cells. Among the pigments, only onion pigment increased the viability of the UV-irradiated cells, indicating that onion pigment had the ability to inhibit the killing effect of UV toward U-937, U-M and HL-60 cells. The inhibiting activity of onion pigment was observed in the water-soluble fraction, but not in the methanol-soluble fraction. Quercetin, a main component of onion pigment, was not effective toward inhibiting the killing effect of UV irradiation on U-937 cells.

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