Evidence for endogenous dopaminergic control of GH release in man.

DOI Web Site Web Site PubMed
  • HANEW KUNIHIKO
    The Second Department of Internal Medicine, Tohoku University School of Medicine
  • SASAKI ATSUSHI
    The Second Department of Internal Medicine, Tohoku University School of Medicine
  • YOSHINAGA KAORU
    The Second Department of Internal Medicine, Tohoku University School of Medicine

Bibliographic Information

Other Title
  • Evidence for Endogenous Dopaminergic Co

Search this article

Abstract

HANEW, K., SASAKI, A. and YOSHINAGA, K. Evidence for Endogenous Dopaminergic Control of GH Release in Man. Tohoku J. exp. Med., 1981, 135 (1), 103-108 - In order to determine whether or not there is a tonic dopamine (DA) control of GH release, the effect of an anti-dopaminergic agent, sulpiride, on GH secretion was studied in 12 normal subjects. After the administration of sulpiride, serum concentrations of sulpiride reached a peak value (1.93±0.1 μg/ml, mean±S.E.M., n=6) at 15min and then showed a gradual decrease. Concomitantly, mean plasma prolactin (PRL) showed a rapid elevation, with a peak value of 161.9±11.5ng/ml at 30min, followed by a gradual decrease. Even at 180min after sulpiride injection, the plasma PRL was still 9 times higher than the initial level (p<0.005). Within 90min after the injection, 12 subjects showed a minimal but significant decrease in GH (from 0.78±0.17 to 0.32±0.03ng/ml, p<0.02). After another 90min, the plasma GH level increased and the mean peak value (8.1±2.7ng/ml) at 180min was significantly higher than the initial value (p<0.02). From these observations, it was suggested that sulpiride inhibited the endogenous DA activity over 180min, and that the GH decrease within 90min was due to a suppression of endogenous DA activity. Factors other than DA, however, might be considered for the GH increase after 90min.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top