OM-173,new nanaomycin-type antibiotics produced by a strain of streptomyces. Taxonomy,production,isolation and biological properties.

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  • IWAI YUZURU
    The Kitasato Institute and School of Pharmaceutical Science, Kitasato University
  • KIMURA KEIKO
    The Kitasato Institute and School of Pharmaceutical Science, Kitasato University
  • TAKAHASHI YOKO
    The Kitasato Institute and School of Pharmaceutical Science, Kitasato University
  • HINOTOZAWA KIYOIZUMI
    The Kitasato Institute and School of Pharmaceutical Science, Kitasato University
  • SHIMIZU HIDEKI
    The Kitasato Institute and School of Pharmaceutical Science, Kitasato University
  • TANAKA HARUO
    The Kitasato Institute and School of Pharmaceutical Science, Kitasato University
  • OMURA SATOSHI
    The Kitasato Institute and School of Pharmaceutical Science, Kitasato University

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  • OM 173 New Nanaomycin type Antibiotics
  • TAXONOMY, PRODUCTION, ISOLATION AND BIOLOGICAL PROPERTIES

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Abstract

Actinomycete strain OM-173, a new soil isolate, was found to produce five nanaomycin-type antibiotics. Antibiotic OM-173 components αA, αE, αB, βA and βE were isolated from the fermentation broth of strain OM-173 by solvent extraction, silica gel chromatography and preparative thin-layer chromatography. The components are active against mycoplasmas and to a lesser extent against fungi. Strain OM-173 was identified as a strain of genus Streptomyces and differed apparently from Streptomyces rosa var. notoensis, the nanaomycin-producing strain, in cultural characteristics.

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