Antithrombogenicity of cultured endothelial cells exposed to blood under stagnant flow conditions
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- Kaibara Makoto
- Computational Biomechanics Unit, RIKEN Wako Institute
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- Yotoriyama Tasuku
- Faculty of Applied Physics, Graduated School, Tokyo University of Science Beam Application Team, RIKEN Wako Institute
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- Himeno Ryutaro
- Computational Biomechanics Unit, RIKEN Wako Institute
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抄録
Antithrombogenicity of cultured bovine aortic endothelial cells exposed to human blood for 2 - 8 hours under a stagnant flow condition was examined using a system consisting of a hybrid vessel model and a damped oscillation rheometer. Exposure of endothelial cells to blood for 8 hours did not cause detachment of the endothelial cells. Only a slight adhesion of platelets to the cells occurred, but no coagulation of platelet-free plasma occurred. These results suggest that the endothelial cells did not suffer from any damage nor injury to cause thrombus formation and coagulation. In contrast to this, under the condition of a damped oscillation, coagulation of whole blood in the vessel model occurred at about 20 min, regardless of the pre-exposure of endothelial cells to blood. This suggests that an extremely slow flow may induce the formation of thrombus or clot on an intact vessel wall. Furthermore, the occurrence of coagulation of blood in contact with endothelial cells supports our previously proposed hypothesis that the activation of factor IX by an enzyme on erythrocyte membranes triggers blood coagulation.
収録刊行物
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- Journal of Japanese Society of Biorheology
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Journal of Japanese Society of Biorheology 18 (1), 52-59, 2004
JAPANESE SOCIETY OF BIORHEOLOGY
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詳細情報 詳細情報について
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- CRID
- 1390282680399289600
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- NII論文ID
- 130004626396
- 40006223232
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- NII書誌ID
- AN10042423
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- NDL書誌ID
- 6945053
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- ISSN
- 09134778
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可