An Unusual Autopsy Case of Pyogenic Liver Abscess Caused by Periodontal Bacteria

DOI Web Site Web Site 3 Citations
  • Ohyama Hideki
    Department of Pathology, Hyogo College of Medicine, Japan
  • Nakasho Keiji
    Department of Pathology, Hyogo College of Medicine, Japan
  • Yamanegi Koji
    Department of Pathology, Hyogo College of Medicine, Japan
  • Noiri Yuichiro
    Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, Japan
  • Kuhara Ayako
    Department of Pathology, Hyogo College of Medicine, Japan
  • Kato-Kogoe Nahoko
    Department of Pathology, Hyogo College of Medicine, Japan
  • Yamada Naoko
    Department of Pathology, Hyogo College of Medicine, Japan
  • Hata Masaki
    Department of Pathology, Hyogo College of Medicine, Japan
  • Nishimura Fusanori
    Department of Dental Science for Health Promotion, Division of Cervico-Gnathostomatology, Hiroshima University Graduate School of Biomedical Sciences, Japan
  • Ebisu Shigeyuki
    Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, Japan
  • Terada Nobuyuki
    Department of Pathology, Hyogo College of Medicine, Japan

Search this article

Abstract

<p>Pyogenic liver abscess (PLA) formation is thought to originate from the transmission of infection via three major routes including the biliary tract, portal vein and hepatic artery. However, about 50% of PLA cases are considered to be cryptogenic. Here we report an unusual autopsy case of PLA associated with periodontopathic bacterial infection. A 59-year-old female suddenly developed cardiopulmonary arrest and died. Despite macroscopic and microscopic examinations, the infectious routes and source of infection were unidentified, and the case appeared to be cryptogenic. Since this patient had suffered severe periodontitis for a long period of time, we investigated the involvement of periodontal infection in PLA formation by performing immunohistochemical analyses. We identified several periodontopathic bacterial species in the PLA of this patient, including Fusobacterium nucleatum, Treponema denticola, Prevotella intermedia and Porphyromonas gingivalis. Thus, we demonstrate here that periodontal infection is a potential source of infection in the formation of PLA.<tt> </tt></p>

Journal

Citations (3)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top