The first autopsy case of pandemic influenza (A/H1N1pdm) virus infection in Japan: detection of a high copy number of the virus in type 2 alveolar epithelial cells by pathological and virological examination
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- Nakajima Noriko
- Department of Pathology, National Institute of Infectious Diseases, Japan
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- Hata Satoru
- Department of Clinical Laboratory, Nagano Red Cross Hospital, Japan
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- Sato Yuko
- Department of Pathology, National Institute of Infectious Diseases, Japan
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- Tobiume Minoru
- Department of Pathology, National Institute of Infectious Diseases, Japan
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- Katano Harutaka
- Department of Pathology, National Institute of Infectious Diseases, Japan
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- Kaneko Keiko
- Department of Pathology, National Institute of Infectious Diseases, Japan
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- Nagata Noriyo
- Department of Pathology, National Institute of Infectious Diseases, Japan
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- Kataoka Michiyo
- Department of Pathology, National Institute of Infectious Diseases, Japan
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- Ainai Akira
- Influenza Virus Research Center, National Institute of Infectious Diseases, Japan
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- Hasegawa Hideki
- Department of Pathology, National Institute of Infectious Diseases, Japan Influenza Virus Research Center, National Institute of Infectious Diseases, Japan
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- Tashiro Masato
- Influenza Virus Research Center, National Institute of Infectious Diseases, Japan
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- Kuroda Makoto
- Pathogen Genomics Center, National Institute of Infectious Diseases, Japan
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- Odai Tamami
- Department of Cardiology, Nagano Red Cross Hospital, Japan
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- Urasawa Nobuyuki
- Department of Cardiology, Nagano Red Cross Hospital, Japan
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- Ogino Tomoyoshi
- Department of Pathology, Nagano Red Cross Hospital, Japan
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- Hanaoka Hiroaki
- Department of Pathology, Nagano Red Cross Hospital, Japan
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- Watanabe Masahide
- Department of Pathology, Nagano Red Cross Hospital, Japan
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- Sata Tetsutaro
- Department of Pathology, National Institute of Infectious Diseases, Japan
書誌事項
- タイトル別名
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- The First Autopsy Case of Pandemic Influenza (A/H1N1pdm) Virus Infection in Japan: Detection of a High Copy Number of the Virus in Type II Alveolar Epithelial Cells by Pathological and Virological Examination
- Short Communication The First Autopsy Case of Pandemic Influenza (A/H1N1pdm) Virus Infection in Japan: Detection of a High Copy Number of the Virus in Type II Alveolar Epithelial Cells by Pathological and Virological Examination
- The first case of pandemic influenza (A/H1N1) virus infection in Japan: Detection of a high copy number of the virus in type II alveolar epithelial cells by pathological and virological examination
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抄録
<p>We report the pathological and virological findings of the first autopsy case of the 2009 pandemic influenza (A/H1N1pdm) virus infection in Japan. A man aged 33 years with chronic heart failure due to dilated cardiomyopathy, mild diabetes mellitus, atopic dermatitis, bronchial asthma, and obesity died of respiratory failure and multiple organ dysfunction syndrome. Macroscopic examination showed severe plumonary edema and microscopically the lung sections showed very early exudative-stage diffuse alveolar damage (DAD). Immunohistochemistry revealed proliferation of the influenza (A/H1N1pdm) virus in alveolar epithelial cells, some of which expressed SAα2-3Gal on the cell surface. Influenza (A/H1N1pdm) virus genomic RNA and mRNA were also detected in alveolar epithelial cells. Real-time PCR revealed 723 copies/cell in the left lower lung section from which the influenza (A/H1N1pdm) virus was isolated. Electron microscopic analysis revealed filamentous viral particles in the lung tissue. The concentrations of various cytokines/chemokines in the serum and the autopsied lung tissue were measured. IL-2R, IL-6, IL-8, IL-10, IFN-α, MCP-1, and MIG levels were elevated in both. These findings indicated a case of viral pneumonia caused by influenza (A/H1N1pdm) virus infection, showing characteristic pathological findings of the early stage of DAD.<tt> </tt></p>
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 63 (1), 67-71, 2010-01-29
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390010292825970944
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- NII論文ID
- 40016938583
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
- http://id.crossref.org/issn/13446304
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- NDL書誌ID
- 10532348
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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